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Query: STUB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STUB1 0 2.750 -1.420 2.320 -0.284 0.442 -0.104

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STUB1 Phosphorylation S23 0.078 0.165 _LGAGGGS(ph)PEKS(ph)PSAQELK_
STUB1 Phosphorylation S19 0.041 0.082 _LGAGGGS(ph)PEKS(ph)PSAQELK_
STUB1 Ubiquitylation K125 0.325 -0.191 _AYSLAK(gl)EQR_
STUB1 Phosphorylation S273 -0.431 -0.250 _S(ph)PLTQEQLIPNLAMK_
STUB1 Ubiquitylation K22 0.017 -0.536 _LGAGGGSPEK(gl)SPSAQELK_
STUB1 Ubiquitylation K30 -0.704 -0.765 _SPSAQELK(gl)EQGNR_
STUB1 Ubiquitylation K41 -0.158 _K(gl)YPEAAACYGR_

Background Information for STUB1:


Pubmed-STUB1 »
Uniprot-STUB1 »
Biogrid-STUB1 »
ProteomicsDB-STUB1 »

Tumorportal-STUB1 »
COSMIC-STUB1 »
GenomeRNAi-STUB1 »
Genecards-STUB1


Protein-protein Interactions for STUB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6AP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait JAK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NHSL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOMM40 Cat. description Hein, Mann, Cell 2015
Category members IP bait ABHD15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C7orf52 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DHX30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCND2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC27A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TYSND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in STUB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR_1 IPR001440 1.39
Category members TPR-contain_dom IPR013026 0.97
Category members TPR_repeat IPR019734 0.93
Category members TPR_2 IPR013105 0.45
Category members Ubox_domain IPR003613 0


Protein complexes (CORUM database) featuring STUB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 432 N-NOS-CHIP-HSP70-1 complex Database 0.47
Category members Corum 6052 BAG3-HSC70-HSPB8-CHIP complex Database 0.32
Category members Corum 6037 CHIP-HSC70 complex Database 0.11
Category members Corum 5980 LRRK2-CHIP-HSP90 complex Database 0


Categories featuring STUB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0042405 nuclear inclusion body Database 0.82
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0019900 kinase binding Database 0.45
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0030911 TPR domain binding Database 0.27
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0.24
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0051865 protein autoubiquitination Database 0.18
Category members GO Category GO:0031371 ubiquitin conjugating enzyme complex Database 0.11
Category members GO Category GO:0030544 Hsp70 protein binding Database 0.1
Category members Pathway Pathway_405 PID_ALPHA_SYNUCLEIN_PATHWAY 0 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0051604 protein maturation Database 0.06
Category members GO Category GO:0006515 misfolded or incompletely synthesized protein catabolic process Database 0.04
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Disease phenotype Cerebellar_ataxia_-_hypogonadism Cerebellar ataxia - hypogonadism Database 0
Category members GO Category GO:0030579 ubiquitin-dependent SMAD protein catabolic process Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0031943 regulation of glucocorticoid metabolic process Database 0
Category members GO Category GO:0034450 ubiquitin-ubiquitin ligase activity Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0051787 misfolded protein binding Database 0
Category members GO Category GO:0051879 Hsp90 protein binding Database 0
Category members GO Category GO:0070534 protein K63-linked ubiquitination Database 0
Category members GO Category GO:0071218 cellular response to misfolded protein Database 0


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