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Query: SORT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SORT1 0 -2.177

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SORT1 Ubiquitylation K294 -0.104 _TSDLGK(gl)SFK_
SORT1 Ubiquitylation K388 -2.073 -0.343 _GIVYSK(gl)SLDR_

Background Information for SORT1:


Pubmed-SORT1 »
Uniprot-SORT1 »
Biogrid-SORT1 »
ProteomicsDB-SORT1 »

Tumorportal-SORT1 »
COSMIC-SORT1 »
GenomeRNAi-SORT1 »
Genecards-SORT1


Protein-protein Interactions for SORT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015


Protein Domains in SORT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BNR_rpt IPR002860 0
Category members VPS10 IPR006581 0


Protein complexes (CORUM database) featuring SORT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1794 SORT1-NGFR complex Database 0
Category members Corum 1795 SORT1-NGFR-NGFB complex Database 0


Categories featuring SORT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0008333 endosome to lysosome transport Database 0.49
Category members GO Category GO:0007218 neuropeptide signaling pathway Database 0.45
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0016050 vesicle organization Database 0.31
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0006895 Golgi to endosome transport Database 0.25
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0048406 nerve growth factor binding Database 0.08
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members GO Category GO:0030140 trans-Golgi network transport vesicle Database 0.03
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0010465 nerve growth factor receptor activity Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0014902 myotube differentiation Database 0
Category members GO Category GO:0032580 Golgi cisterna membrane Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0038180 nerve growth factor signaling pathway Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0046323 glucose import Database 0
Category members GO Category GO:0048227 plasma membrane to endosome transport Database 0
Category members GO Category GO:0051005 negative regulation of lipoprotein lipase activity Database 0


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