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Query: SMARCA2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMARCA2 0 1.104 -0.270 0.240 -0.431 -0.133 0.253 0.069 -0.280

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMARCA2 Ubiquitylation K381 0.558 1.360 _ATVELK(gl)ALR_
SMARCA2 Phosphorylation S329 -0.314 -0.351 _IS(ph)PIQKPQGLDPVEILQER_
SMARCA2 Phosphorylation S1377 -0.887 -1.142 _GRPPAEKLS(ph)PNPPK_
SMARCA2 Ubiquitylation K333 -1.365 _ISPIQK(gl)PQGLDPVEILQER_
SMARCA2 Ubiquitylation K413 -0.238 _DTTLETALNSK(gl)AYKR_

Background Information for SMARCA2:


Pubmed-SMARCA2 »
Uniprot-SMARCA2 »
Biogrid-SMARCA2 »
ProteomicsDB-SMARCA2 »

Tumorportal-SMARCA2 »
COSMIC-SMARCA2 »
GenomeRNAi-SMARCA2 »
Genecards-SMARCA2


Protein-protein Interactions for SMARCA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL7C Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMARCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTBL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RELB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SS18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMARCA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Bromodomain IPR001487 1.43
Category members HAS_subgr IPR013999 0.68
Category members Helicase/SANT-assoc_DNA-bd IPR014012 0.68
Category members Gln-Leu-Gln_QLQ IPR014978 0.28
Category members BRK_domain IPR006576 0
Category members RNaseH-like_dom IPR012337 0


Protein complexes (CORUM database) featuring SMARCA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 714 BRM-SIN3A complex Database 4.02
Category members Corum 1230 WINAC complex Database 3.79
Category members Corum 806 BRM-SIN3A-HDAC complex Database 2.48
Category members Corum 1237 BAF complex Database 2.03
Category members Corum 238 SWI-SNF chromatin remodeling-related-BRCA1 complex Database 1.57
Category members Corum 711 Brm-associated complex Database 1.57
Category members Corum 808 BRM-associated complex Database 1.57
Category members Corum 189 BAF complex Database 1.36
Category members Corum 5184 SWI/SNF chromatin-remodeling complex Database 1.23
Category members Corum 3066 RNA polymerase II complex, chromatin structure modifying Database 0.92
Category members Corum 5158 SMARCA2/BRM-BAF57-MECP2 complex Database 0.43


Categories featuring SMARCA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0016514 SWI/SNF complex Database 2.12
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Disease phenotype Coffin_Siris Coffin Siris Database 0.43
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0035887 aortic smooth muscle cell differentiation Database 0.28
Category members GO Category GO:0045111 intermediate filament cytoskeleton Database 0.26
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0016817 hydrolase activity, acting on acid anhydrides Database 0.06
Category members Disease phenotype intellectual_disability_-_sparse_hair_-_brachydactyly intellectual disability - sparse hair - brachydactyly Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0001105 RNA polymerase II transcription coactivator activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007399 nervous system development Database 0


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