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Query: SMAD5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMAD5 0 -3.729 0.640 -0.430

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMAD5 Ubiquitylation K64 -2.082 -1.647 _ALSSPGQPSK(gl)CVTIPR_

Background Information for SMAD5:


Pubmed-SMAD5 »
Uniprot-SMAD5 »
Biogrid-SMAD5 »
ProteomicsDB-SMAD5 »

Tumorportal-SMAD5 »
COSMIC-SMAD5 »
GenomeRNAi-SMAD5 »
Genecards-SMAD5


Protein-protein Interactions for SMAD5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C7orf45 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IPPK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMURF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMAD5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SMAD_FHA_domain IPR008984 0.86
Category members SMAD_dom_Dwarfin-type IPR001132 0
Category members MAD_homology1_Dwarfin-type IPR003619 0
Category members MAD_homology_MH1 IPR013019 0
Category members Interferon_reg_factor-3 IPR019471 0


Protein complexes (CORUM database) featuring SMAD5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SMAD5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_995 PID_ALK1_PATHWAY 0 0.69
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0030218 erythrocyte differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1211 REACTOME_SIGNALING_BY_BMP 0 0.04
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members Pathway Pathway_1209 PID_ALK2_PATHWAY 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001880 Mullerian duct regression Database 0
Category members GO Category GO:0002051 osteoblast fate commitment Database 0
Category members GO Category GO:0005057 receptor signaling protein activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007281 germ cell development Database 0
Category members GO Category GO:0009880 embryonic pattern specification Database 0
Category members GO Category GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Database 0
Category members GO Category GO:0045669 positive regulation of osteoblast differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051216 cartilage development Database 0
Category members GO Category GO:0060048 cardiac muscle contraction Database 0
Category members GO Category GO:0060348 bone development Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


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