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Query: SIX1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SIX1 0 0.636 1.730 -1.230 -0.334 0.495

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SIX1 Ubiquitylation K53 0.475 _AK(gl)AVVAFHR_

Background Information for SIX1:


Pubmed-SIX1 »
Uniprot-SIX1 »
Biogrid-SIX1 »
ProteomicsDB-SIX1 »

Tumorportal-SIX1 »
COSMIC-SIX1 »
GenomeRNAi-SIX1 »
Genecards-SIX1


Protein-protein Interactions for SIX1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ERCC6L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SIX1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Homeobox_dom IPR001356 0.63
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring SIX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SIX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0048856 anatomical structure development Database 0.33
Category members GO Category GO:0030855 epithelial cell differentiation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0048699 generation of neurons Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members Disease phenotype Autosomal_dominant_nonsyndromic_sensorineural_deafness_type_DFNA Autosomal dominant nonsyndromic sensorineural deafness type DFNA Database 0
Category members Disease phenotype BOR_syndrome BOR syndrome Database 0
Category members Disease phenotype Branchio-otic_syndrome Branchio-otic syndrome Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0001759 organ induction Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0008582 regulation of synaptic growth at neuromuscular junction Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0021610 facial nerve morphogenesis Database 0
Category members GO Category GO:0030878 thyroid gland development Database 0
Category members GO Category GO:0032880 regulation of protein localization Database 0
Category members GO Category GO:0035909 aorta morphogenesis Database 0
Category members GO Category GO:0042472 inner ear morphogenesis Database 0
Category members GO Category GO:0042474 middle ear morphogenesis Database 0
Category members GO Category GO:0045664 regulation of neuron differentiation Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0048665 neuron fate specification Database 0
Category members GO Category GO:0048705 skeletal system morphogenesis Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0051451 myoblast migration Database 0
Category members GO Category GO:0060037 pharyngeal system development Database 0


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