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Query: SFPQ

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SFPQ 1 8.434 -1.880 4.270 0.328 0.568 -0.141 -0.140 0.032

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SFPQ Ubiquitylation K332 1.002 1.454 _GK(gl)GFGFIK_
SFPQ Ubiquitylation K466 -0.093 1.182 _LAQK(gl)NPMYQK_
SFPQ Ubiquitylation K421 0.383 1.058 _GIVEFASK(gl)PAAR_
SFPQ Phosphorylation S273 0.863 0.625 _SEEKIS(ph)DSEGFK_
SFPQ Ubiquitylation K413 0.957 0.529 _STGK(gl)GIVEFASKPAAR_
SFPQ Ubiquitylation K559 -0.148 0.186 _MEELHNQEMQK(gl)R_
SFPQ Phosphorylation T687 -1.833 _GMGPGT(ph)PAGYGR_
SFPQ Ubiquitylation K271 0.191 _SEEK(gl)ISDSEGFK_
SFPQ Ubiquitylation K291 0.067 _RPGEK(gl)TYTQR_
SFPQ Ubiquitylation K330 0.013 _YGEPGEVFINK(gl)GK_
SFPQ Ubiquitylation K338 0.958 _GFGFIK(gl)LESR_

Background Information for SFPQ:


Pubmed-SFPQ »
Uniprot-SFPQ »
Biogrid-SFPQ »
ProteomicsDB-SFPQ »

Tumorportal-SFPQ »
COSMIC-SFPQ »
GenomeRNAi-SFPQ »
Genecards-SFPQ


Protein-protein Interactions for SFPQ
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CXXC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIN7C Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM98A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIP1R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NONO Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SFPQ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SFPQ
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members NOPS IPR012975 0


Protein complexes (CORUM database) featuring SFPQ
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1335 SNW1 complex Database 3.59
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 1760 TOP1-PSF-P54 complex Database 0.17
Category members Corum 335 p54(nrb)-PSF-matrin3 complex Database 0.17
Category members Corum 1148 snRNP-free U1A (SF-A) complex Database 0.05
Category members Corum 330 PSF-p54(nrb) complex Database 0.04


Categories featuring SFPQ
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0000380 alternative mRNA splicing, via spliceosome Database 0.29
Category members GO Category GO:0042382 paraspeckles Database 0.23
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Disease phenotype Translocation_renal_cell_carcinoma Translocation renal cell carcinoma Database 0


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