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Query: SDC4

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SDC4 0 -0.979 1.110 -0.650

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SDC4 Ubiquitylation K190 -0.979 _K(gl)APTNEFYA_

Background Information for SDC4:


Pubmed-SDC4 »
Uniprot-SDC4 »
Biogrid-SDC4 »
ProteomicsDB-SDC4 »

Tumorportal-SDC4 »
COSMIC-SDC4 »
GenomeRNAi-SDC4 »
Genecards-SDC4


Protein-protein Interactions for SDC4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR183 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SDC4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Neurexin-like IPR003585 0
Category members Syndecan/Neurexin_dom IPR027789 0


Protein complexes (CORUM database) featuring SDC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SDC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_73 REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 0 1.71
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0030203 glycosaminoglycan metabolic process Database 1.44
Category members GO Category GO:0043034 costamere Database 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0005796 Golgi lumen Database 0.64
Category members Pathway Pathway_471 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM 0 0.6
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members Pathway Pathway_79 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM 0 0.49
Category members GO Category GO:0030204 chondroitin sulfate metabolic process Database 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_478 REACTOME_HS_GAG_BIOSYNTHESIS 0 0.31
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members Pathway Pathway_1093 PID_SYNDECAN_4_PATHWAY 0 0.28
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members Pathway Pathway_479 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS 0 0.21
Category members GO Category GO:0006024 glycosaminoglycan biosynthetic process Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0001523 retinoid metabolic process Database 0.1
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0043202 lysosomal lumen Database 0.07
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members GO Category GO:0006027 glycosaminoglycan catabolic process Database 0.05
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members Pathway Pathway_76 REACTOME_HS_GAG_DEGRADATION 0 0.03
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_740 PID_INTEGRIN3_PATHWAY 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001968 fibronectin binding Database 0
Category members GO Category GO:0008150 biological_process Database 0
Category members GO Category GO:0051496 positive regulation of stress fiber assembly Database 0
Category members GO Category GO:0051894 positive regulation of focal adhesion assembly Database 0
Category members GO Category GO:0070053 thrombospondin receptor activity Database 0


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