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Query: RUVBL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RUVBL2 1 8.899 -2.210 5.080 0.796 0.479 0.807 0.364 0.491

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RUVBL2 Ubiquitylation K427 0.479 0.403 _K(gl)GTEVQVDDIK(gl)R_
RUVBL2 Ubiquitylation K9 -0.203 -0.294 _(ac)ATVTATTK(gl)VPEIRDVTR_
RUVBL2 Ubiquitylation K368 -0.345 _LLIVSTTPYSEKDTK(gl)QILR_
RUVBL2 Ubiquitylation K365 -0.355 -0.601 _LLIVSTTPYSEK(gl)DTK_
RUVBL2 Ubiquitylation K234 -0.191 -0.742 _FVQCPDGELQK(gl)R_
RUVBL2 Ubiquitylation K417 -1.196 _K(gl)GTEVQVDDIK(gl)R_
RUVBL2 Ubiquitylation K160 0.331 _VGK(gl)LTLK_
RUVBL2 Ubiquitylation K186 -0.554 _DK(gl)VQAGDVITIDK_

Background Information for RUVBL2:


Pubmed-RUVBL2 »
Uniprot-RUVBL2 »
Biogrid-RUVBL2 »
ProteomicsDB-RUVBL2 »

Tumorportal-RUVBL2 »
COSMIC-RUVBL2 »
GenomeRNAi-RUVBL2 »
Genecards-RUVBL2


Protein-protein Interactions for RUVBL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ING3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PFDN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR3E Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TRRAP Cat. description Hein, Mann, Cell 2015
Category members IP bait YEATS4 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ACTR8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C20orf20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMKK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRTAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MEAF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MORF4L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIH1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RDM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUVBL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUVBL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UCHL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RUVBL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members AAA+_ATPase IPR003593 0.38
Category members TIP49_C IPR010339 0.35
Category members ATPase_AAA_core IPR003959 0.14
Category members DNA_helicase_DnaB-like_C IPR007694 0


Protein complexes (CORUM database) featuring RUVBL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 781 URI complex (Unconventional prefoldin RPB5 Interactor) Database 0.77
Category members Corum 1166 p400-associated complex Database 0.68
Category members Corum 525 TIP60 histone acetylase complex Database 0.62
Category members Corum 2857 NuA4/Tip60 HAT complex Database 0.28
Category members Corum 798 NuA4/Tip60-HAT complex A Database 0.28
Category members Corum 787 NuA4/Tip60-HAT complex B Database 0.23
Category members Corum 1170 cMYC-ATPase-helicase complex Database 0.16
Category members Corum 1171 c-MYC-ATPase-helicase complex Database 0.16
Category members Corum 302 INO80 chromatin remodeling complex Database 0.14
Category members Corum 1173 TIP49-TIP48-BAF53 complex Database 0.13
Category members Corum 528 NuA4/Tip60 HAT complex Database 0.07
Category members Corum 799 DMAP1-associated complex Database 0.05
Category members Corum 529 NuA4/Tip60 HAT complex Database 0.04
Category members Corum 304 SRCAP-associated chromatin remodeling complex Database 0


Categories featuring RUVBL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members GO Category GO:0071339 MLL1 complex Database 0.45
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0031011 Ino80 complex Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043141 ATP-dependent 5'-3' DNA helicase activity Database 0.25
Category members Pathway Pathway_858 PID_MYC_PATHWAY 0 0.17
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0035267 NuA4 histone acetyltransferase complex Database 0.07
Category members GO Category GO:0043968 histone H2A acetylation Database 0.02
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0040008 regulation of growth Database 0
Category members GO Category GO:0043967 histone H4 acetylation Database 0


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