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Query: RAC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAC2 1 3.868 -1.520 2.710 0.486 -0.364 -0.568

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAC2 Ubiquitylation K185 -0.113 0.578 _GLK(gl)TVFDEAIR_
RAC2 Ubiquitylation K172 1.026 0.412 _EIGAVK(gl)YLECSALTQR_
RAC2 Ubiquitylation K115 -1.745 -0.215 _AK(gl)WYPEVR_
RAC2 Ubiquitylation K152 0.099 -0.292 _K(gl)LTPITYPQGLAMAK_
RAC2 Ubiquitylation K166 -0.981 -0.655 _LTPITYPQGLAMAK(gl)EIGAVK_
RAC2 Ubiquitylation K202 -1.379 -1.447 _AVLCPPPVK(gl)KR_
RAC2 Ubiquitylation K203 -1.708 -1.447 _AVLCPPPVKK(gl)_
RAC2 Ubiquitylation K142 0.492 _LDLRDDK(gl)DTIEK_

Background Information for RAC2:


Pubmed-RAC2 »
Uniprot-RAC2 »
Biogrid-RAC2 »
ProteomicsDB-RAC2 »

Tumorportal-RAC2 »
COSMIC-RAC2 »
GenomeRNAi-RAC2 »
Genecards-RAC2


Protein-protein Interactions for RAC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RAC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Ran_GTPase IPR002041 1.25
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase_Ras IPR020849 0.7
Category members Small_GTPase_Rho IPR003578 0.65
Category members Small_GTPase IPR001806 0.65
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32


Protein complexes (CORUM database) featuring RAC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RAC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0006935 chemotaxis Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_642 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE 0 0.02
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1035 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010310 regulation of hydrogen peroxide metabolic process Database 0
Category members GO Category GO:0030031 cell projection assembly Database 0
Category members GO Category GO:0045453 bone resorption Database 0
Category members GO Category GO:0060263 regulation of respiratory burst Database 0


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