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Query: RAB5A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAB5A 0 0.731 -0.440 0.910 0.089 -0.362
RAB5A 0 0.731 -0.440 0.910 0.074 0.374 -1.305
RAB5A 0 0.731 0.080 0.240 0.089 -0.362
RAB5A 0 0.731 0.080 0.240 0.074 0.374 -1.305

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAB5A Ubiquitylation K174 0.735 _ADLASK(gl)R_
RAB5A Ubiquitylation K150 0.290 0.396 _NWVK(gl)ELQR_
RAB5A Ubiquitylation K168 -0.721 -0.117 _QASPNIVIALAGNK(gl)ADLASK_

Background Information for RAB5A:


Pubmed-RAB5A »
Uniprot-RAB5A »
Biogrid-RAB5A »
ProteomicsDB-RAB5A »

Tumorportal-RAB5A »
COSMIC-RAB5A »
GenomeRNAi-RAB5A »
Genecards-RAB5A


Protein-protein Interactions for RAB5A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RAB5A Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAB5A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Ran_GTPase IPR002041 1.25
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase_Ras IPR020849 0.7
Category members Small_GTPase_Rho IPR003578 0.65
Category members Small_GTPase IPR001806 0.65
Category members Gtr1_RagA IPR006762 0.63
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32


Protein complexes (CORUM database) featuring RAB5A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2572 RAB5-EEA1 complex Database 0
Category members Corum 2573 Class C VPS/HOPS complex Database 0


Categories featuring RAB5A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_63 BIOCARTA_PTDINS_PATHWAY 0 0.91
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members Pathway Pathway_1273 BIOCARTA_RAB_PATHWAY 0 0.18
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members GO Category GO:0019003 GDP binding Database 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0019001 guanyl nucleotide binding Database 0.07
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0051489 regulation of filopodium assembly Database 0.04
Category members Pathway Pathway_663 PID_IL8_CXCR1_PATHWAY 0 0.01
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members Pathway Pathway_422 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0045921 positive regulation of exocytosis Database 0


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