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Query: PDIA3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PDIA3 2 8.612 -2.160 3.830 0.189 2.142 -1.800
PDIA3 2 8.612 -2.160 3.830 0.411 2.714 -0.864 0.952 0.794

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PDIA3 Ubiquitylation K130 0.775 _TADGIVSHLKK(gl)_
PDIA3 Ubiquitylation K94 -0.012 0.658 _VDCTANTNTCNK(gl)YGVSGYPTLK_
PDIA3 Ubiquitylation K226 -0.163 0.525 _TVAYTEQK(gl)MTSGK_
PDIA3 Ubiquitylation K75 -0.105 _LK(gl)GIVPLAK_
PDIA3 Ubiquitylation K362 -0.242 _FLQDYFDGNLK(gl)R_

Background Information for PDIA3:


Pubmed-PDIA3 »
Uniprot-PDIA3 »
Biogrid-PDIA3 »
ProteomicsDB-PDIA3 »

Tumorportal-PDIA3 »
COSMIC-PDIA3 »
GenomeRNAi-PDIA3 »
Genecards-PDIA3


Protein-protein Interactions for PDIA3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6AP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLU Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait INSR Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KBTBD7 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait TGFBR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait INHA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDIA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PDIA3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Disulphide_isomerase IPR005788 1.41
Category members Thioredoxin_domain IPR013766 0.49
Category members Prot_disulphide_isomerase IPR005792 0.42
Category members Thioredoxin-like_fold IPR012336 0.16


Protein complexes (CORUM database) featuring PDIA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 280 HMGB1-HMGB2-HSC70-ERP60-GAPDH complex Database 1.56


Categories featuring PDIA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0006457 protein folding Database 4.93
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_765 REACTOME_ER_PHAGOSOME_PATHWAY 0 2.74
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0003756 protein disulfide isomerase activity Database 1.21
Category members GO Category GO:0006662 glycerol ether metabolic process Database 0.79
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_766 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 0 0.47
Category members GO Category GO:0004197 cysteine-type endopeptidase activity Database 0.38
Category members GO Category GO:0016853 isomerase activity Database 0.37
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0004629 phospholipase C activity Database 0.23
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members GO Category GO:0006621 protein retention in ER lumen Database 0.04
Category members Pathway Pathway_464 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE 0 0
Category members Pathway Pathway_465 REACTOME_CALNEXIN_CALRETICULIN_CYCLE 0 0
Category members Pathway Pathway_94 REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 0 0
Category members Pathway Pathway_95 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION 0 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0015035 protein disulfide oxidoreductase activity Database 0
Category members GO Category GO:0018279 protein N-linked glycosylation via asparagine Database 0
Category members GO Category GO:0043687 post-translational protein modification Database 0


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