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Query: NSD1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NSD1 0 0.364 -0.750 1.060 -0.118 -0.211

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NSD1 Phosphorylation S1510 0.148 _TATS(ph)PKETVEEGVEHDPGMPASK_
NSD1 Phosphorylation S2471 -0.515 -0.677 _AAS(ph)PHQVTPQADEK_

Background Information for NSD1:


Pubmed-NSD1 »
Uniprot-NSD1 »
Biogrid-NSD1 »
ProteomicsDB-NSD1 »

Tumorportal-NSD1 »
COSMIC-NSD1 »
GenomeRNAi-NSD1 »
Genecards-NSD1


Protein-protein Interactions for NSD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GAR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MECP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFY Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF692 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NSD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_PHD IPR001965 1.15
Category members Znf_PHD-finger IPR019787 0.91
Category members PWWP_dom IPR000313 0.63
Category members SET_dom IPR001214 0.29
Category members Post-SET_dom IPR003616 0.03
Category members AWS_dom IPR006560 0


Protein complexes (CORUM database) featuring NSD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NSD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005694 chromosome Database 3.87
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0016922 ligand-dependent nuclear receptor binding Database 0.89
Category members Pathway Pathway_22 KEGG_LYSINE_DEGRADATION 0 0.8
Category members GO Category GO:0018024 histone-lysine N-methyltransferase activity Database 0.73
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0016571 histone methylation Database 0.08
Category members GO Category GO:0010452 histone H3-K36 methylation Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0042974 retinoic acid receptor binding Database 0.02
Category members GO Category GO:0046966 thyroid hormone receptor binding Database 0
Category members Disease phenotype BECKWITH-WIEDEMANN_SYNDROME BECKWITH-WIEDEMANN SYNDROME Database 0
Category members Disease phenotype Weaver_syndrome Weaver syndrome Database 0
Category members GO Category GO:0001702 gastrulation with mouth forming second Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0030331 estrogen receptor binding Database 0
Category members GO Category GO:0034770 histone H4-K20 methylation Database 0
Category members GO Category GO:0042054 histone methyltransferase activity Database 0
Category members GO Category GO:0042799 histone methyltransferase activity (H4-K20 specific) Database 0
Category members GO Category GO:0046965 retinoid X receptor binding Database 0
Category members GO Category GO:0046975 histone methyltransferase activity (H3-K36 specific) Database 0


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