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Query: NR3C1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NR3C1 0 -0.542 0.390 -0.260

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NR3C1 Ubiquitylation K696 0.338 _MTYIK(gl)ELGK_
NR3C1 Phosphorylation S226 -0.070 _SDLLIDENCLLS(ph)PLAGEDDSFLLEGNSNEDCKPLILPDTKPK_
NR3C1 Phosphorylation S45 -0.810 -0.399 _VSASS(ph)PSLAVASQSDSK_

Background Information for NR3C1:


Pubmed-NR3C1 »
Uniprot-NR3C1 »
Biogrid-NR3C1 »
ProteomicsDB-NR3C1 »

Tumorportal-NR3C1 »
COSMIC-NR3C1 »
GenomeRNAi-NR3C1 »
Genecards-NR3C1


Protein-protein Interactions for NR3C1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CERK Cat. description Hein, Mann, Cell 2015
Category members IP bait MBOAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NR3C1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Nucl_hrmn_rcpt_lig-bd_core IPR000536 0
Category members Znf_hrmn_rcpt IPR001628 0
Category members Str_hrmn_rcpt IPR001723 0
Category members Nucl_hormone_rcpt_ligand-bd IPR008946 0


Protein complexes (CORUM database) featuring NR3C1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 4216 GR-hnRNP U complex Database 0


Categories featuring NR3C1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_1184 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 0 1.89
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members Pathway Pathway_748 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 0 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0030325 adrenal gland development Database 0.52
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members GO Category GO:0042921 glucocorticoid receptor signaling pathway Database 0.04
Category members GO Category GO:0008211 glucocorticoid metabolic process Database 0.04
Category members Pathway Pathway_1044 BIOCARTA_NTHI_PATHWAY 0 0
Category members Pathway Pathway_439 BIOCARTA_GCR_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_929 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY 0 0
Category members GO Category GO:0003707 steroid hormone receptor activity Database 0
Category members GO Category GO:0005496 steroid binding Database 0
Category members GO Category GO:0006111 regulation of gluconeogenesis Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0043401 steroid hormone mediated signaling pathway Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0060603 mammary gland duct morphogenesis Database 0


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