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Query: NME2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NME2 0 -1.670 0.040 0.180 -0.783 0.303 -0.394 -0.805 -0.898

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NME2 Ubiquitylation K264 0.448 0.582 _NIIHGSDSVK(gl)SAEK_
NME2 Ubiquitylation K51 -0.368 0.345 _GLVGEIIK(gl)R_
NME2 Ubiquitylation K37 0.192 0.188 _TFIAIK(gl)PDGVQR_
NME2 Ubiquitylation K125 -0.693 -0.414 _VMLGETNPADSK(gl)PGTIR_
NME2 Ubiquitylation K56 -0.240 _FEQK(gl)GFR_

Background Information for NME2:


Pubmed-NME2 »
Uniprot-NME2 »
Biogrid-NME2 »
ProteomicsDB-NME2 »

Tumorportal-NME2 »
COSMIC-NME2 »
GenomeRNAi-NME2 »
Genecards-NME2


Protein-protein Interactions for NME2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CFB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DAO Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NME3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC48A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMOC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRABD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WWOX Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NME2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Nucleoside_diP_kinase IPR001564 0


Protein complexes (CORUM database) featuring NME2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NME2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0071398 cellular response to fatty acid Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Database 0.21
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0019215 intermediate filament binding Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0014075 response to amine Database 0.11
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0045682 regulation of epidermis development Database 0.1
Category members Pathway Pathway_297 BIOCARTA_NDKDYNAMIN_PATHWAY 0 0.08
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_274 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES 0 0
Category members GO Category GO:0002762 negative regulation of myeloid leukocyte differentiation Database 0
Category members GO Category GO:0004550 nucleoside diphosphate kinase activity Database 0
Category members GO Category GO:0006165 nucleoside diphosphate phosphorylation Database 0
Category members GO Category GO:0006183 GTP biosynthetic process Database 0
Category members GO Category GO:0006228 UTP biosynthetic process Database 0
Category members GO Category GO:0006241 CTP biosynthetic process Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0009142 nucleoside triphosphate biosynthetic process Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0015949 nucleobase-containing small molecule interconversion Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0033574 response to testosterone Database 0
Category members GO Category GO:0043015 gamma-tubulin binding Database 0
Category members GO Category GO:0045618 positive regulation of keratinocyte differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0071333 cellular response to glucose stimulus Database 0


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