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Query: NFIB

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NFIB 0 3.547 -1.030 1.080 -0.711 0.025 0.306 1.031

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NFIB Phosphorylation S325 0.852 _KPEKPLFS(ph)SASPQDSSPR_
NFIB Phosphorylation T314 0.827 _DQDMSSPT(ph)TMK_
NFIB Phosphorylation S312 0.764 0.746 _DQDMSS(ph)PTTMK_
NFIB Phosphorylation S311 1.021 0.671 _DQDMS(ph)SPTTM(ox)K_
NFIB Phosphorylation S328 1.295 0.637 _KPEKPLFSSAS(ph)PQDSSPR_
NFIB Phosphorylation S332 -0.428 -1.102 _KPEKPLFSSASPQDS(ph)SPR_
NFIB Phosphorylation S294 -1.873 _TISIDENM(ox)EPSPTGDFYPSPS(ph)SPAAGSR_
NFIB Phosphorylation S295 -1.280 _TISIDENMEPSPTGDFYPSPSS(ph)PAAGSR_
NFIB Phosphorylation S300 -1.728 _TISIDENM(ox)EPSPTGDFYPSPSSPAAGS(ph)R_
NFIB Phosphorylation S333 -0.428 _KPEKPLFSSASPQDS(ph)SPR_

Background Information for NFIB:


Pubmed-NFIB »
Uniprot-NFIB »
Biogrid-NFIB »
ProteomicsDB-NFIB »

Tumorportal-NFIB »
COSMIC-NFIB »
GenomeRNAi-NFIB »
Genecards-NFIB


Protein-protein Interactions for NFIB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CRY1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait SASS6 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait NFIB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NFIB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31
Category members CTF/NFI IPR000647 0
Category members MAD_homology1_Dwarfin-type IPR003619 0
Category members CTF/NFI_DNA-bd_N IPR019548 0
Category members CTF/NFI_DNA-bd-dom IPR020604 0


Protein complexes (CORUM database) featuring NFIB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NFIB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_353 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION 0 0.29
Category members Pathway Pathway_357 REACTOME_RNA_POL_III_TRANSCRIPTION 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0001106 RNA polymerase II transcription corepressor activity Database 0.06
Category members GO Category GO:0021740 principal sensory nucleus of trigeminal nerve development Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030902 hindbrain development Database 0.02
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members GO Category GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010001 glial cell differentiation Database 0
Category members GO Category GO:0021960 anterior commissure morphogenesis Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0044300 cerebellar mossy fiber Database 0
Category members GO Category GO:0060486 Clara cell differentiation Database 0
Category members GO Category GO:0060509 Type I pneumocyte differentiation Database 0
Category members GO Category GO:0060510 Type II pneumocyte differentiation Database 0


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