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Query: MYH9

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MYH9 1 4.125 -1.530 2.620 0.366 -0.040 -0.375 0.136 -0.183

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MYH9 Ubiquitylation K760 0.409 0.964 _IGQSK(gl)VFFR_
MYH9 Ubiquitylation K403 0.390 0.869 _DYVQK(gl)AQTK_
MYH9 Ubiquitylation K1415 0.790 _VAAYDKLEKTK(gl)_
MYH9 Phosphorylation S1943 0.168 0.290 _KGAGDGS(ph)DEEVDGKADGAEAK_
MYH9 Ubiquitylation K860 -0.570 0.212 _VREK(gl)QLAAENR_
MYH9 Ubiquitylation K66 0.545 _VK(gl)VNKDDIQK_
MYH9 Ubiquitylation K682 -0.508 _AGK(gl)LDPHLVLDQLR_
MYH9 Ubiquitylation K821 -0.339 _NCAAYLK(gl)LR_
MYH9 Ubiquitylation K856 -1.336 _EEELVK(gl)VR_
MYH9 Ubiquitylation K1274 0.036 _VRTELADK(gl)VTK_
MYH9 Ubiquitylation K1277 0.081 _TELADKVTK(gl)_
MYH9 Ubiquitylation K1413 0.288 _VAAYDKLEK(gl)TK_

Background Information for MYH9:


Pubmed-MYH9 »
Uniprot-MYH9 »
Biogrid-MYH9 »
ProteomicsDB-MYH9 »

Tumorportal-MYH9 »
COSMIC-MYH9 »
GenomeRNAi-MYH9 »
Genecards-MYH9


Protein-protein Interactions for MYH9
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYL12A;MYL12B Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMM50 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MYH9
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Myosin_head_motor_dom IPR001609 0.17
Category members tRNA-bd_arm IPR010978 0.08
Category members Regulat_G_prot_signal_superfam IPR016137 0.05
Category members IQ_motif_EF-hand-BS IPR000048 0
Category members Myosin_tail IPR002928 0
Category members Myosin_N IPR004009 0
Category members Myosin_S1_N IPR008989 0
Category members Prefoldin IPR009053 0
Category members STAT_TF_coiled-coil IPR015988 0


Protein complexes (CORUM database) featuring MYH9
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5604 Emerin complex 1 Database 0.62
Category members Corum 486 WIP-WASp-actin-myosin-IIa complex Database 0.31


Categories featuring MYH9
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members GO Category GO:0008180 COP9 signalosome Database 1.47
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0051295 establishment of meiotic spindle localization Database 0.74
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0030224 monocyte differentiation Database 0.45
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0016459 myosin complex Database 0.38
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0030898 actin-dependent ATPase activity Database 0.31
Category members GO Category GO:0031532 actin cytoskeleton reorganization Database 0.29
Category members GO Category GO:0030048 actin filament-based movement Database 0.28
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members GO Category GO:0000146 microfilament motor activity Database 0.27
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0030863 cortical cytoskeleton Database 0.24
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members GO Category GO:0006509 membrane protein ectodomain proteolysis Database 0.14
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007520 myoblast fusion Database 0.11
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0038032 termination of G-protein coupled receptor signaling pathway Database 0.05
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members GO Category GO:0008305 integrin complex Database 0.03
Category members GO Category GO:0016460 myosin II complex Database 0.03
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1035 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 0 0
Category members Disease phenotype Autosomal_dominant_nonsyndromic_sensorineural_deafness_type_DFNA Autosomal dominant nonsyndromic sensorineural deafness type DFNA Database 0
Category members GO Category GO:0000212 meiotic spindle organization Database 0
Category members GO Category GO:0000904 cell morphogenesis involved in differentiation Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001768 establishment of T cell polarity Database 0
Category members GO Category GO:0001772 immunological synapse Database 0
Category members GO Category GO:0001931 uropod Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005826 actomyosin contractile ring Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0030220 platelet formation Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0032796 uropod organization Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043495 protein anchor Database 0
Category members GO Category GO:0043534 blood vessel endothelial cell migration Database 0


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