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Query: MIF

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MIF 0 -2.468 1.480 -0.910 -0.887 -0.872 -1.709 0.653

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MIF Ubiquitylation K78 0.018 0.329 _SYSK(gl)LLCGLLAER_

Background Information for MIF:


Pubmed-MIF »
Uniprot-MIF »
Biogrid-MIF »
ProteomicsDB-MIF »

Tumorportal-MIF »
COSMIC-MIF »
GenomeRNAi-MIF »
Genecards-MIF


Protein-protein Interactions for MIF
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MKNK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS26A Cat. description Hein, Mann, Cell 2015


Protein Domains in MIF
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Macrophage_inhib_fac IPR001398 0
Category members Tautomerase/MIF_sf IPR014347 0


Protein complexes (CORUM database) featuring MIF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MIF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0005125 cytokine activity Database 1.06
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0042327 positive regulation of phosphorylation Database 0.52
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0070207 protein homotrimerization Database 0.16
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members GO Category GO:0001516 prostaglandin biosynthetic process Database 0.09
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members GO Category GO:0030330 DNA damage response, signal transduction by p53 class mediator Database 0.04
Category members GO Category GO:0050715 positive regulation of cytokine secretion Database 0.03
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0007569 cell aging Database 0.03
Category members Pathway Pathway_154 KEGG_TYROSINE_METABOLISM 0 0
Category members Pathway Pathway_398 KEGG_PHENYLALANINE_METABOLISM 0 0
Category members Disease phenotype RHEUMATOID_ARTHRITIS_SYSTEMIC_JUVENILE RHEUMATOID ARTHRITIS SYSTEMIC JUVENILE Database 0
Category members Disease phenotype Systemic-onset_juvenile_idiopathic_arthritis Systemic-onset juvenile idiopathic arthritis Database 0
Category members GO Category GO:0002906 negative regulation of mature B cell apoptotic process Database 0
Category members GO Category GO:0004167 dopachrome isomerase activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005126 cytokine receptor binding Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0010739 positive regulation of protein kinase A signaling Database 0
Category members GO Category GO:0019752 carboxylic acid metabolic process Database 0
Category members GO Category GO:0030890 positive regulation of B cell proliferation Database 0
Category members GO Category GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway Database 0
Category members GO Category GO:0032269 negative regulation of cellular protein metabolic process Database 0
Category members GO Category GO:0033033 negative regulation of myeloid cell apoptotic process Database 0
Category members GO Category GO:0042056 chemoattractant activity Database 0
Category members GO Category GO:0043030 regulation of macrophage activation Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0050918 positive chemotaxis Database 0
Category members GO Category GO:0071157 negative regulation of cell cycle arrest Database 0


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