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Query: MARK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MARK2 2 8.815 0.390 -0.570 -0.342 -0.924

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MARK2 Phosphorylation S390 5.149 4.932 _PSADLTNSSAPS(ph)PSHK_
MARK2 Phosphorylation S387 3.794 _PSADLTNSS(ph)APSPSHK_
MARK2 Phosphorylation S486 -0.028 0.163 _SRNS(ph)PLLER_
MARK2 Phosphorylation S569 -0.860 -0.742 _VPVAS(ph)PSAHNISSSGGAPDR_
MARK2 Phosphorylation S456 -1.253 -1.182 _VPAS(ph)PLPGLER_
MARK2 Phosphorylation S571 -0.724 _VPVASPS(ph)AHNISSSGGAPDR_

Background Information for MARK2:


Pubmed-MARK2 »
Uniprot-MARK2 »
Biogrid-MARK2 »
ProteomicsDB-MARK2 »

Tumorportal-MARK2 »
COSMIC-MARK2 »
GenomeRNAi-MARK2 »
Genecards-MARK2


Protein-protein Interactions for MARK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APC Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait DLG5 Cat. description Hein, Mann, Cell 2015
Category members IP bait LDHD Cat. description Hein, Mann, Cell 2015
Category members IP bait MARK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SOGA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAV3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COL4A3BP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUCA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MANSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAP1L5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUAK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MARK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UBA/transl_elong_EF1B_N_euk IPR015940 0.04
Category members Kinase-like_dom IPR011009 0.03
Category members KA1/Ssp2_C IPR028375 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members KA1_dom IPR001772 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring MARK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5199 Kinase maturation complex 1 Database 3.38


Categories featuring MARK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0030010 establishment of cell polarity Database 0.91
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0045180 basal cortex Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0051493 regulation of cytoskeleton organization Database 0.04
Category members GO Category GO:0050321 tau-protein kinase activity Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity Database 0
Category members GO Category GO:0050770 regulation of axonogenesis Database 0


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