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Query: LAMA2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LAMA2 0 -0.600 1.640 -0.040
LAMA2 0 -0.600 1.640 -0.040 -0.260

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LAMA2 Ubiquitylation K2038 -0.340 _LQAVK(gl)DKAR_
LAMA2 Ubiquitylation K2040 -0.340 _LQAVK(gl)DKAR_

Background Information for LAMA2:


Pubmed-LAMA2 »
Uniprot-LAMA2 »
Biogrid-LAMA2 »
ProteomicsDB-LAMA2 »

Tumorportal-LAMA2 »
COSMIC-LAMA2 »
GenomeRNAi-LAMA2 »
Genecards-LAMA2


Protein-protein Interactions for LAMA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ENTHD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA10 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC6 Cat. description Hein, Mann, Cell 2015


Protein Domains in LAMA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members Laminin_G IPR001791 0.06
Category members t-SNARE IPR010989 0.04
Category members EGF_laminin IPR002049 0.04
Category members Laminin_B_type_IV IPR000034 0
Category members Laminin_N IPR008211 0
Category members Galactose-bd-like IPR008979 0
Category members ConA-like_lec_gl_sf IPR008985 0
Category members Prefoldin IPR009053 0
Category members Laminin_I IPR009254 0
Category members Laminin_domII IPR010307 0
Category members Laminin_B_subgr IPR018031 0


Protein complexes (CORUM database) featuring LAMA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LAMA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0022011 myelination in peripheral nervous system Database 0.33
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1290 PID_INTEGRIN4_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members Disease phenotype Congenital_Muscular_Dystrophy Congenital Muscular Dystrophy Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0005605 basal lamina Database 0
Category members GO Category GO:0005606 laminin-1 complex Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0032224 positive regulation of synaptic transmission, cholinergic Database 0
Category members GO Category GO:0045995 regulation of embryonic development Database 0


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