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Query: ITPR1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITPR1 2 7.411 -0.040 0.000 0.768 0.643
ITPR1 2 7.411 -0.040 0.000 1.489 1.835

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITPR1 Phosphorylation S2670 1.132 1.555 _LGFVDVQNCIS(ph)R_
ITPR1 Phosphorylation S1832 0.650 0.560 _VAS(ph)FSIPGSSSR_
ITPR1 Phosphorylation S1598 1.165 0.362 _RDS(ph)VLAASR_
ITPR1 Ubiquitylation K2628 -0.010 _ILQDK(gl)LNSTMK_
ITPR1 Phosphorylation S937 -0.026 _KQSVFS(ph)APSLSAGASAAEPLDR_
ITPR1 Ubiquitylation K1534 -0.220 _TLAMVAK(gl)GR_
ITPR1 Phosphorylation S934 0.318 -0.802 _KQS(ph)VFSAPSLSAGASAAEPLDR_
ITPR1 Ubiquitylation K2597 -0.819 _NK(gl)NLDWFPR_
ITPR1 Ubiquitylation K529 1.377 _EK(gl)GGEGPLVR_

Background Information for ITPR1:


Pubmed-ITPR1 »
Uniprot-ITPR1 »
Biogrid-ITPR1 »
ProteomicsDB-ITPR1 »

Tumorportal-ITPR1 »
COSMIC-ITPR1 »
GenomeRNAi-ITPR1 »
Genecards-ITPR1


Protein-protein Interactions for ITPR1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2H5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait CA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA0748 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB7L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITPR1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members InsP3_rcpt-bd IPR000493 0.65
Category members RIH_dom IPR000699 0.14
Category members RIH_assoc-dom IPR013662 0.14
Category members Ins145_P3_rcpt IPR014821 0.14
Category members MIR_motif IPR016093 0.03
Category members Ion_trans_dom IPR005821 0


Protein complexes (CORUM database) featuring ITPR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 553 RHOA-IP3R-TRPC1 complex Database 0.04


Categories featuring ITPR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0005637 nuclear inner membrane Database 1.98
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0032469 endoplasmic reticulum calcium ion homeostasis Database 1.26
Category members GO Category GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Database 0.91
Category members GO Category GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0035091 phosphatidylinositol binding Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0031095 platelet dense tubular network membrane Database 0.45
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0005955 calcineurin complex Database 0.39
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members GO Category GO:0015085 calcium ion transmembrane transporter activity Database 0.27
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members Pathway Pathway_625 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 0 0.26
Category members GO Category GO:0070588 calcium ion transmembrane transport Database 0.25
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members GO Category GO:0006811 ion transport Database 0.18
Category members Pathway Pathway_514 ST_GAQ_PATHWAY 0 0.17
Category members GO Category GO:0005216 ion channel activity Database 0.16
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0031088 platelet dense granule membrane Database 0.12
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_735 ST_MYOCYTE_AD_PATHWAY 0 0.09
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members GO Category GO:0005262 calcium channel activity Database 0.08
Category members GO Category GO:0031094 platelet dense tubular network Database 0.07
Category members GO Category GO:0005218 intracellular ligand-gated calcium channel activity Database 0.06
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members Pathway Pathway_306 ST_WNT_CA2_CYCLIC_GMP_PATHWAY 0 0.03
Category members GO Category GO:0048016 inositol phosphate-mediated signaling Database 0.03
Category members GO Category GO:0051209 release of sequestered calcium ion into cytosol Database 0.01
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007202 activation of phospholipase C activity Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0016529 sarcoplasmic reticulum Database 0
Category members GO Category GO:0050882 voluntary musculoskeletal movement Database 0


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