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Query: HSPA8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSPA8 2 9.882 -0.640 0.320 0.616 0.207 0.569 0.697 0.187

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSPA8 Ubiquitylation K348 0.390 3.929 _IQK(gl)LLQDFFNGK_
HSPA8 Ubiquitylation K159 0.192 2.025 _QATK(gl)DAGTIAGLNVLR_
HSPA8 Ubiquitylation K71 0.041 1.713 _NQVAM(ox)NPTNTVFDAK(gl)R_
HSPA8 Ubiquitylation K56 -0.260 1.224 _LIGDAAK(gl)NQVAMNPTNTVFDAK(gl)R_
HSPA8 Ubiquitylation K500 0.066 1.038 _ENK(gl)ITITNDK_
HSPA8 Ubiquitylation K108 0.301 0.877 _VQVEYK(gl)GETK_
HSPA8 Ubiquitylation K451 0.095 0.846 _AMTK(gl)DNNLLGK_
HSPA8 Ubiquitylation K187 0.744 _IINEPTAAAIAYGLDK(gl)K_
HSPA8 Ubiquitylation K188 -0.076 0.744 _IINEPTAAAIAYGLDKK(gl)_
HSPA8 Ubiquitylation K512 0.321 0.692 _LSK(gl)EDIER_
HSPA8 Ubiquitylation K328 -0.057 0.670 _LDK(gl)SQIHDIVLVGGSTR_
HSPA8 Ubiquitylation K497 0.354 0.667 _STGK(gl)ENKITITNDK_
HSPA8 Ubiquitylation K126 -0.071 0.472 _SFYPEEVSSMVLTK(gl)MK_
HSPA8 Ubiquitylation K128 1.160 0.420 _MK(gl)EIAEAYLGK_
HSPA8 Ubiquitylation K539 -0.121 0.409 _VSSK(gl)NSLESYAFNMK_
HSPA8 Ubiquitylation K526 4.133 0.230 _MVQEAEKYK(gl)AEDEK_
HSPA8 Ubiquitylation K601 0.005 0.196 _ELEK(gl)VCNPIITK_
HSPA8 Ubiquitylation K507 -0.228 -0.104 _ITITNDK(gl)GR_
HSPA8 Ubiquitylation K524 0.032 -0.180 _M(ox)VQEAEK(gl)YKAEDEKQR_
HSPA8 Ubiquitylation K557 -0.270 _ATVEDEK(gl)LQGK_
HSPA8 Ubiquitylation K319 0.026 -0.313 _GTLDPVEK(gl)ALR_
HSPA8 Ubiquitylation K325 0.501 -0.341 _ALRDAK(gl)LDK_
HSPA8 Ubiquitylation K3 -0.324 _(ac)SK(gl)GPAVGIDLGTTYSCVGVFQHGK_
HSPA8 Ubiquitylation K357 0.339 _LLQDFFNGK(gl)ELNK_
HSPA8 Ubiquitylation K531 1.093 _MVQEAEK(gl)YKAEDEK(gl)QR_
HSPA8 Ubiquitylation K597 0.282 _NQTAEKEEFEHQQK(gl)ELEK_

Background Information for HSPA8:


Pubmed-HSPA8 »
Uniprot-HSPA8 »
Biogrid-HSPA8 »
ProteomicsDB-HSPA8 »

Tumorportal-HSPA8 »
COSMIC-HSPA8 »
GenomeRNAi-HSPA8 »
Genecards-HSPA8


Protein-protein Interactions for HSPA8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1107 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF1C Cat. description Hein, Mann, Cell 2015
Category members IP bait LRPPRC Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SDHAF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TGFBR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ABHD15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AGPAT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ALOXE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARHGEF16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARMC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARNT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BBS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BPNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf45 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1orf94 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C20orf96 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C21orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C3orf37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C7orf45 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf116 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC117 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDKL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHD1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHI3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CNN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPLX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSNK1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSNK1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP8B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCDC2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DENND2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DET1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGCR14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DHX57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DOCK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DSCR4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPB42 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOC3L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait F12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM187B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM73B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCRL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FKSG43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FLYWCH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXRED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GFAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNA15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HCFC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IER2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ILK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCND2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNJ10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNV2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1967 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL36 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LEPREL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPGAT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC56 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait METTL21A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPZL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MVP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NLRX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NMNAT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NOX5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPAS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PANK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDPK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNPLA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POC1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPEF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKACG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRODH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTGIR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTRF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SETMAR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SF3A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC27A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA5L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAF6L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBC1D23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THAP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THSD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM16L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRMT12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPYL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSSK1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTC30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TYSND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VANGL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VILL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF434 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF488 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSPA8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HSP70_C IPR029048 0.66
Category members HSP70_peptide-bd IPR029047 0.55
Category members MreB_Mrl IPR004753 0.4
Category members Hsp_70_fam IPR013126 0.4


Protein complexes (CORUM database) featuring HSPA8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 929 CEN complex Database 3.25
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 280 HMGB1-HMGB2-HSC70-ERP60-GAPDH complex Database 1.56
Category members Corum 725 P2X7 receptor signalling complex Database 0.53
Category members Corum 1178 BCOR complex Database 0.34
Category members Corum 6052 BAG3-HSC70-HSPB8-CHIP complex Database 0.32
Category members Corum 2837 Profilin 1 complex Database 0.21
Category members Corum 6037 CHIP-HSC70 complex Database 0.11
Category members Corum 1182 CDC5L core complex Database 0.08
Category members Corum 1308 PABPC1-HSPA8-HNRPD-EIF4G1 complex Database 0.04
Category members Corum 2129 DNAJB2-HSPA8-PSMA3 complex Database 0
Category members Corum 2300 Profilin 2 complex Database 0


Categories featuring HSPA8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Pathway Pathway_776 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 0 1.45
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0006892 post-Golgi vesicle-mediated transport Database 0.74
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0006986 response to unfolded protein Database 0.62
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_473 REACTOME_LYSOSOME_VESICLE_BIOGENESIS 0 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members Pathway Pathway_389 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 0 0.04
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_390 REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0000974 Prp19 complex Database 0
Category members GO Category GO:0007269 neurotransmitter secretion Database 0
Category members GO Category GO:0042623 ATPase activity, coupled Database 0
Category members GO Category GO:0051085 chaperone mediated protein folding requiring cofactor Database 0
Category members GO Category GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane Database 0


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