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Query: FEN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FEN1 0 3.086 -1.360 2.210 0.895 1.036 -1.389 -0.361 -0.414

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FEN1 Ubiquitylation K354 1.109 _VTGSLSSAK(gl)R_

Background Information for FEN1:


Pubmed-FEN1 »
Uniprot-FEN1 »
Biogrid-FEN1 »
ProteomicsDB-FEN1 »

Tumorportal-FEN1 »
COSMIC-FEN1 »
GenomeRNAi-FEN1 »
Genecards-FEN1


Protein-protein Interactions for FEN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FEN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRPPRC Cat. description Hein, Mann, Cell 2015
Category members IP bait LTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1R21 Cat. description Hein, Mann, Cell 2015
Category members IP bait WHSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTL6A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DUSP19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTCRA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FEN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members XPG-I_dom IPR006086 0.17
Category members HhH2 IPR008918 0.17
Category members 5-3_exonuclease_C IPR020045 0.17
Category members XPG_DNA_repair_N IPR006085 0
Category members PIN_domain-like IPR029060 0


Protein complexes (CORUM database) featuring FEN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2197 FEN1-9-1-1 complex Database 0.39


Categories featuring FEN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_859 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 0 1.34
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members GO Category GO:0009650 UV protection Database 0.68
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members Pathway Pathway_860 KEGG_NON_HOMOLOGOUS_END_JOINING 0 0.52
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members Pathway Pathway_340 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND 0 0.24
Category members Pathway Pathway_311 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 0 0.2
Category members GO Category GO:0008409 5'-3' exonuclease activity Database 0.13
Category members Pathway Pathway_316 REACTOME_LAGGING_STRAND_SYNTHESIS 0 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0048256 flap endonuclease activity Database 0.04
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_335 REACTOME_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_337 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0004523 ribonuclease H activity Database 0
Category members GO Category GO:0004527 exonuclease activity Database 0
Category members GO Category GO:0007613 memory Database 0
Category members GO Category GO:0017108 5'-flap endonuclease activity Database 0
Category members GO Category GO:0030145 manganese ion binding Database 0
Category members GO Category GO:0043137 DNA replication, removal of RNA primer Database 0


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