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Query: DYRK1A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DYRK1A 0 3.954 -1.360 2.390

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DYRK1A Phosphorylation Y321 0.876 0.924 _IYQY(ph)IQSR_
DYRK1A Ubiquitylation K11 -0.236 _(ac)MHTGGETSACK(gl)PSSVR_

Background Information for DYRK1A:


Pubmed-DYRK1A »
Uniprot-DYRK1A »
Biogrid-DYRK1A »
ProteomicsDB-DYRK1A »

Tumorportal-DYRK1A »
COSMIC-DYRK1A »
GenomeRNAi-DYRK1A »
Genecards-DYRK1A


Protein-protein Interactions for DYRK1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TBP;TBPL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C10orf71 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM117B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM53C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FNTB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRCH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LZTS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKACB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFPL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DYRK1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring DYRK1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DYRK1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0048156 tau protein binding Database 0.11
Category members Disease phenotype Autosomal_dominant_non-syndromic_intellectual_disability Autosomal dominant non-syndromic intellectual disability Database 0.08
Category members GO Category GO:0043621 protein self-association Database 0.07
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1154 BIOCARTA_SHH_PATHWAY 0 0
Category members Pathway Pathway_869 REACTOME_G0_AND_EARLY_G1 0 0
Category members Disease phenotype AUTISM AUTISM Database 0
Category members GO Category GO:0004712 protein serine/threonine/tyrosine kinase activity Database 0
Category members GO Category GO:0004715 non-membrane spanning protein tyrosine kinase activity Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator Database 0


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