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Autosomal dominant non-syndromic intellectual disability
(Autosomal_dominant_non-syndromic_intellectual_disability)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
EPB41L1 2 -0.670 1.160 0.965 -0.443 -0.532 0.843 0.638
EPB41L1 2 -0.670 1.160 -0.401
DYNC1H1 1 -0.620 0.440 0.066 0.428 0.323
DOCK8 0 0.230 -0.930 -0.289
DOCK8 0 0.230 -0.930 -1.046 0.305 0.146
KIF1A 0 0.540 -0.550 0.592
KIF1A 0 0.540 -0.550 0.715 -0.651
DYRK1A 0 -1.360 2.390
CTNNB1 0 0.490 -0.230
CTNNB1 0 0.490 -0.230 -0.415 0.628 0.215

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CTNNB1 Ubiquitylation K158 -1.265 _AIPELTK(gl)LLNDEDQVVVNK_
CTNNB1 Ubiquitylation K180 -0.546 -0.636 _AAVM(ox)VHQLSK(gl)K_
CTNNB1 Ubiquitylation K181 -0.717 -0.729 _AAVMVHQLSKK(gl)_
CTNNB1 Phosphorylation S191 -0.024 0.129 _S(ph)PQMVSAIVR_
CTNNB1 Ubiquitylation K435 -0.350 _NK(gl)MM(ox)VCQVGGIEALVR_
CTNNB1 Ubiquitylation K496 -1.262 _LHYGLPVVVK(gl)_
CTNNB1 Phosphorylation S552 1.233 1.224 _RTS(ph)MGGTQQQFVEGVR_
CTNNB1 Phosphorylation T556 1.275 0.995 _RTSM(ox)GGT(ph)QQQFVEGVR_
CTNNB1 Ubiquitylation K671 -0.941 -0.934 _MSEDKPQDYK(gl)K_
DOCK8 Phosphorylation S180 0.319 0.371 _S(ph)MSIDDTPR_
DOCK8 Ubiquitylation K381 0.138 _LK(gl)SQADQFCQR_
DOCK8 Phosphorylation S452 1.041 1.249 _TTS(ph)GDDACNLTSFR_
DOCK8 Phosphorylation S888 0.502 0.610 _SAVRPAS(ph)LNLNR_
DOCK8 Phosphorylation S896 -0.852 _S(ph)LSNSNPDISGTPTSPDDEVR_
DOCK8 Phosphorylation S898 -2.241 -0.434 _SLS(ph)NSNPDISGTPTSPDDEVR_
DOCK8 Phosphorylation S900 -0.947 -3.303 _SLSNS(ph)NPDISGT(ph)PTSPDDEVR_
DOCK8 Phosphorylation T907 -0.613 -0.434 _SLS(ph)NSNPDISGT(ph)PTSPDDEVR_
DOCK8 Phosphorylation S910 -0.268 -0.548 _SLS(ph)NSNPDISGTPTS(ph)PDDEVR_
DOCK8 Phosphorylation S929 0.481 0.241 _SNS(ph)WVNTGGPK_
DOCK8 Phosphorylation S946 0.288 _AAPWGSNPS(ph)PSAESTQAMDR_
DOCK8 Phosphorylation S1383 1.049 1.056 _MNS(ph)LTFK_
DOCK8 Phosphorylation S1432 0.204 0.208 _SPS(ph)GSAFGSQENLR_
DOCK8 Phosphorylation S1438 -0.052 -0.235 _SPSGSAFGS(ph)QENLR_
DOCK8 Ubiquitylation K2080 0.971 _NK(gl)SLIGPDQKEYQR_
DOCK8 Ubiquitylation K2088 0.652 _SLIGPDQK(gl)EYQR_
DOCK8 Phosphorylation S2129 0.410 _AVLPVTCHRDS(ph)FSR_
DYNC1H1 Ubiquitylation K120 1.681 _SNSLAFIK(gl)R_
DYNC1H1 Ubiquitylation K634 -1.630 _VQYPQSQACK(gl)MSHVR_
DYNC1H1 Ubiquitylation K652 -1.130 _DLPPVSGSIIWAK(gl)QIDR_
DYNC1H1 Ubiquitylation K683 2.176 _LK(gl)QDGDSFR_
DYNC1H1 Ubiquitylation K734 -1.416 1.572 _TGNVLK(gl)LK_
DYNC1H1 Ubiquitylation K1099 1.697 _GTFDNAETK(gl)K_
DYNC1H1 Ubiquitylation K1100 1.697 _GTFDNAETK(gl)K_
DYNC1H1 Ubiquitylation K1115 0.283 _VQSK(gl)VNLK_
DYNC1H1 Ubiquitylation K1917 0.777 _TESVK(gl)ALGHQLGR_
DYNC1H1 Ubiquitylation K2043 1.456 _SLAMTK(gl)PDR_
DYNC1H1 Ubiquitylation K2104 1.446 _SVLVSAGNVK(gl)R_
DYNC1H1 Ubiquitylation K2239 0.473 _VLLK(gl)ALER_
DYNC1H1 Ubiquitylation K2702 0.744 _TSDQTWVK(gl)LER_
DYNC1H1 Ubiquitylation K3471 0.638 _ADLAAVEAK(gl)VNR_
DYNC1H1 Ubiquitylation K3581 0.233 0.270 _WQASSLPADDLCTENAIMLK(gl)R_
DYNC1H1 Ubiquitylation K3621 0.586 0.363 _K(gl)NLESALR_
DYNC1H1 Ubiquitylation K3757 -0.959 0.797 _SLLQALNEVK(gl)GR_
DYNC1H1 Ubiquitylation K4089 0.723 _AINTAVK(gl)SGR_
DYNC1H1 Ubiquitylation K4204 2.901 _YAPLGWSKK(gl)_
DYNC1H1 Phosphorylation T4366 0.372 _T(ph)DSTSDGRPAWMR_
DYNC1H1 Phosphorylation S4368 0.495 0.826 _TDS(ph)TSDGRPAWMR_
DYRK1A Ubiquitylation K11 -0.236 _(ac)MHTGGETSACK(gl)PSSVR_
DYRK1A Phosphorylation Y321 0.876 0.924 _IYQY(ph)IQSR_
EPB41L1 Phosphorylation S95 2.058 1.653 _SQVS(ph)EEEGKEVESDKEK_
EPB41L1 Phosphorylation S188 0.343 0.603 _IEVKEES(ph)PQSK_
EPB41L1 Phosphorylation S191 0.304 _IEVKEESPQS(ph)K_
EPB41L1 Ubiquitylation K198 0.148 _AETELK(gl)ASQKPIRK_
EPB41L1 Ubiquitylation K237 1.265 1.069 _GQDLLK(gl)R_
EPB41L1 Ubiquitylation K361 0.451 _LAPNQTK(gl)ELEEK_
EPB41L1 Ubiquitylation K366 0.532 _ELEEK(gl)VMELHK_
EPB41L1 Ubiquitylation K372 0.922 _VMELHK(gl)SYR_
EPB41L1 Phosphorylation T475 0.990 1.178 _SEAEEGEVRT(ph)PTK_
EPB41L1 Ubiquitylation K499 -0.476 _SK(gl)FLALGSK_
EPB41L1 Phosphorylation S510 0.594 _HQAS(ph)INELKR_
EPB41L1 Phosphorylation S542 0.751 0.712 _S(ph)LDGAAAVDSADR_
EPB41L1 Phosphorylation S544 -0.490 -0.553 _RLPSSPAS(ph)PSPK_
EPB41L1 Phosphorylation S551 -0.139 _SLDGAAAVDS(ph)ADRSPRPTSAPAITQGQVAEGGVLDASAK_
EPB41L1 Phosphorylation S555 -0.200 -1.109 _SLDGAAAVDSADRS(ph)PRPTSAPAITQGQVAEGGVLDASAK_
EPB41L1 Phosphorylation S560 -0.232 0.037 _SPRPTS(ph)APAITQGQVAEGGVLDASAK_
EPB41L1 Phosphorylation S709 0.307 _RLS(ph)THSPFR_
EPB41L1 Phosphorylation S712 -0.493 0.130 _LSTHS(ph)PFR_
EPB41L1 Phosphorylation S784 0.234 0.250 _SLS(ph)PIIGK_
KIF1A Ubiquitylation K243 0.567 0.154 _VSK(gl)ISLVDLAGSER_
KIF1A Ubiquitylation K373 0.989 _ELK(gl)DEVTR_
KIF1A Phosphorylation S425 0.226 0.513 _AAS(ph)VSSLHER_
KIF1A Phosphorylation S428 0.256 _AASVSS(ph)LHER_
KIF1A Ubiquitylation K685 -0.482 -1.308 _LEALQK(gl)QMDSR_
KIF1A Ubiquitylation K753 -0.683 _EANAISVELK(gl)K_
KIF1A Ubiquitylation K754 -1.146 -0.455 _EANAISVELKK(gl)_
KIF1A Ubiquitylation K977 -0.660 -0.529 _VAIVSEK(gl)GEVK_
KIF1A Ubiquitylation K1011 -1.711 -0.039 _QSGTAK(gl)ISFDDQHFEK_
KIF1A Ubiquitylation K1140 -1.790 -1.571 _HDEAFSTEPLK(gl)NTGR_
KIF1A Phosphorylation S1195 -0.738 -0.620 _DVLS(ph)PLRPSR_
KIF1A Phosphorylation S1446 0.354 0.201 _VTGVYELSLCHVADAGS(ph)PGMQR_
KIF1A Phosphorylation S1477 0.580 0.528 _S(ph)DSLILDHQWELEK_
KIF1A Phosphorylation S1479 0.245 0.345 _SDS(ph)LILDHQWELEK_
KIF1A Ubiquitylation K1563 -5.831 1.045 _ELAVK(gl)CLR_
KIF1A Phosphorylation S1602 0.026 -0.209 _DPS(ph)MSPLGVATLTPSSTCPSLVEGR_
KIF1A Phosphorylation S1604 -0.266 _DPSMS(ph)PLGVATLTPSSTCPSLVEGR_
KIF1A Phosphorylation S1641 -1.145 -1.108 _PAS(ph)PEPELLPEADSK_
KIF1A Ubiquitylation K1687 -1.299 _VSPIVSK(gl)K_
KIF1A Ubiquitylation K1688 -1.299 _VSPIVSK(gl)K_


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