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Query: DOCK8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DOCK8 0 3.570 0.230 -0.930 -1.046 0.305 0.146
DOCK8 0 3.570 0.230 -0.930 -0.289

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DOCK8 Phosphorylation S452 1.041 1.249 _TTS(ph)GDDACNLTSFR_
DOCK8 Phosphorylation S1383 1.049 1.056 _MNS(ph)LTFK_
DOCK8 Phosphorylation S888 0.502 0.610 _SAVRPAS(ph)LNLNR_
DOCK8 Phosphorylation S2129 0.410 _AVLPVTCHRDS(ph)FSR_
DOCK8 Phosphorylation S180 0.319 0.371 _S(ph)MSIDDTPR_
DOCK8 Phosphorylation S946 0.288 _AAPWGSNPS(ph)PSAESTQAMDR_
DOCK8 Phosphorylation S929 0.481 0.241 _SNS(ph)WVNTGGPK_
DOCK8 Phosphorylation S1432 0.204 0.208 _SPS(ph)GSAFGSQENLR_
DOCK8 Ubiquitylation K381 0.138 _LK(gl)SQADQFCQR_
DOCK8 Phosphorylation S1438 -0.052 -0.235 _SPSGSAFGS(ph)QENLR_
DOCK8 Phosphorylation S898 -2.241 -0.434 _SLS(ph)NSNPDISGTPTSPDDEVR_
DOCK8 Phosphorylation T907 -0.613 -0.434 _SLS(ph)NSNPDISGT(ph)PTSPDDEVR_
DOCK8 Phosphorylation S910 -0.268 -0.548 _SLS(ph)NSNPDISGTPTS(ph)PDDEVR_
DOCK8 Phosphorylation S896 -0.852 _S(ph)LSNSNPDISGTPTSPDDEVR_
DOCK8 Phosphorylation S900 -0.947 -3.303 _SLSNS(ph)NPDISGT(ph)PTSPDDEVR_
DOCK8 Ubiquitylation K2080 0.971 _NK(gl)SLIGPDQKEYQR_
DOCK8 Ubiquitylation K2088 0.652 _SLIGPDQK(gl)EYQR_

Background Information for DOCK8:


Pubmed-DOCK8 »
Uniprot-DOCK8 »
Biogrid-DOCK8 »
ProteomicsDB-DOCK8 »

Tumorportal-DOCK8 »
COSMIC-DOCK8 »
GenomeRNAi-DOCK8 »
Genecards-DOCK8


Protein-protein Interactions for DOCK8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MORC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NSMAF Cat. description Hein, Mann, Cell 2015
Category members IP bait PFKFB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARPC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DOCK8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRCH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DOCK8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members DOCK_C IPR010703 0
Category members DOCK_C/D_N IPR021816 0


Protein complexes (CORUM database) featuring DOCK8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DOCK8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Disease phenotype Autosomal_dominant_non-syndromic_intellectual_disability Autosomal dominant non-syndromic intellectual disability Database 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0


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