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Query: DYNC1H1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DYNC1H1 1 6.202 -0.620 0.440 0.066 0.428 0.323

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DYNC1H1 Ubiquitylation K4204 2.901 _YAPLGWSKK(gl)_
DYNC1H1 Ubiquitylation K683 2.176 _LK(gl)QDGDSFR_
DYNC1H1 Ubiquitylation K1099 1.697 _GTFDNAETK(gl)K_
DYNC1H1 Ubiquitylation K1100 1.697 _GTFDNAETK(gl)K_
DYNC1H1 Ubiquitylation K120 1.681 _SNSLAFIK(gl)R_
DYNC1H1 Ubiquitylation K734 -1.416 1.572 _TGNVLK(gl)LK_
DYNC1H1 Ubiquitylation K2043 1.456 _SLAMTK(gl)PDR_
DYNC1H1 Ubiquitylation K2104 1.446 _SVLVSAGNVK(gl)R_
DYNC1H1 Phosphorylation S4368 0.495 0.826 _TDS(ph)TSDGRPAWMR_
DYNC1H1 Ubiquitylation K3757 -0.959 0.797 _SLLQALNEVK(gl)GR_
DYNC1H1 Ubiquitylation K1917 0.777 _TESVK(gl)ALGHQLGR_
DYNC1H1 Ubiquitylation K2702 0.744 _TSDQTWVK(gl)LER_
DYNC1H1 Ubiquitylation K3471 0.638 _ADLAAVEAK(gl)VNR_
DYNC1H1 Ubiquitylation K2239 0.473 _VLLK(gl)ALER_
DYNC1H1 Ubiquitylation K3621 0.586 0.363 _K(gl)NLESALR_
DYNC1H1 Ubiquitylation K1115 0.283 _VQSK(gl)VNLK_
DYNC1H1 Ubiquitylation K3581 0.233 0.270 _WQASSLPADDLCTENAIMLK(gl)R_
DYNC1H1 Ubiquitylation K634 -1.630 _VQYPQSQACK(gl)MSHVR_
DYNC1H1 Ubiquitylation K652 -1.130 _DLPPVSGSIIWAK(gl)QIDR_
DYNC1H1 Ubiquitylation K4089 0.723 _AINTAVK(gl)SGR_
DYNC1H1 Phosphorylation T4366 0.372 _T(ph)DSTSDGRPAWMR_

Background Information for DYNC1H1:


Pubmed-DYNC1H1 »
Uniprot-DYNC1H1 »
Biogrid-DYNC1H1 »
ProteomicsDB-DYNC1H1 »

Tumorportal-DYNC1H1 »
COSMIC-DYNC1H1 »
GenomeRNAi-DYNC1H1 »
Genecards-DYNC1H1


Protein-protein Interactions for DYNC1H1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C14ORF10;PPP2R3C Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait CREBBP Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1H1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1LI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLRB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAFAH1B1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNCA Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNC1I1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DYNC1I2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DYNC1LI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DYNC1H1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members AAA+_ATPase IPR003593 0.38
Category members Dynein_heavy_dom IPR004273 0.29
Category members Dynein_heavy_dom-2 IPR013602 0.29
Category members Glutathione-S-Trfase_C-like IPR010987 0.23
Category members Thioredoxin-like_fold IPR012336 0.16
Category members Dynein_heavy_dom-1 IPR013594 0


Protein complexes (CORUM database) featuring DYNC1H1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1183 CDC5L complex Database 2.07


Categories featuring DYNC1H1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members Pathway Pathway_729 PID_LIS1_PATHWAY 0 1.41
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0007018 microtubule-based movement Database 0.75
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0003777 microtubule motor activity Database 0.49
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members GO Category GO:0007052 mitotic spindle organization Database 0.41
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030286 dynein complex Database 0.27
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0034063 stress granule assembly Database 0.13
Category members Disease phenotype Autosomal_dominant_non-syndromic_intellectual_disability Autosomal dominant non-syndromic intellectual disability Database 0.08
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0033962 cytoplasmic mRNA processing body assembly Database 0.07
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members GO Category GO:0005868 cytoplasmic dynein complex Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0042623 ATPase activity, coupled Database 0


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