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Query: DYNC2H1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DYNC2H1 0 2.321 -1.530 1.820 -0.319 0.050
DYNC2H1 0 2.321 -1.530 1.820 0.313

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DYNC2H1 Ubiquitylation K158 0.457 _SDTNLTK(gl)LK_
DYNC2H1 Ubiquitylation K1248 -0.579 _AADLK(gl)DLNSR_
DYNC2H1 Ubiquitylation K398 -0.876 _IIAPAEQK(gl)IAGK_
DYNC2H1 Ubiquitylation K2613 -1.117 _LNSTDLKDVIKK(gl)_
DYNC2H1 Ubiquitylation K2608 -1.364 _LNSTDLK(gl)DVIKK_

Background Information for DYNC2H1:


Pubmed-DYNC2H1 »
Uniprot-DYNC2H1 »
Biogrid-DYNC2H1 »
ProteomicsDB-DYNC2H1 »

Tumorportal-DYNC2H1 »
COSMIC-DYNC2H1 »
GenomeRNAi-DYNC2H1 »
Genecards-DYNC2H1


Protein-protein Interactions for DYNC2H1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C14ORF10;PPP2R3C Cat. description Hein, Mann, Cell 2015
Category members IP bait COBLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EVPL Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC1;RP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait GDI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF1C Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PXDC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPC24 Cat. description Hein, Mann, Cell 2015
Category members IP bait TIGD6 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VANGL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRYL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DYNC2LI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MOCS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DYNC2H1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members AAA+_ATPase IPR003593 0.38
Category members Dynein_heavy_dom IPR004273 0.29
Category members Dynein_heavy_dom-2 IPR013602 0.29
Category members Dynein_heavy_dom-1 IPR013594 0


Protein complexes (CORUM database) featuring DYNC2H1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DYNC2H1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0007018 microtubule-based movement Database 0.75
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0003777 microtubule motor activity Database 0.49
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030286 dynein complex Database 0.27
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0007030 Golgi organization Database 0.13
Category members Pathway Pathway_266 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 0 0
Category members Disease phenotype Jeune_syndrome Jeune syndrome Database 0
Category members Disease phenotype Short_rib-polydactyly_syndrome_Majewski_type Short rib-polydactyly syndrome Majewski type Database 0
Category members Disease phenotype Short_rib-polydactyly_syndrome_Verma-Naumoff_type Short rib-polydactyly syndrome Verma-Naumoff type Database 0
Category members GO Category GO:0001539 ciliary or bacterial-type flagellar motility Database 0
Category members GO Category GO:0007368 determination of left/right symmetry Database 0
Category members GO Category GO:0008105 asymmetric protein localization Database 0
Category members GO Category GO:0009953 dorsal/ventral pattern formation Database 0
Category members GO Category GO:0021522 spinal cord motor neuron differentiation Database 0
Category members GO Category GO:0030031 cell projection assembly Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031512 motile primary cilium Database 0
Category members GO Category GO:0042384 cilium assembly Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0060271 cilium morphogenesis Database 0


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