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Query: DNA2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DNA2 1 0.847 1.707

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DNA2 Ubiquitylation K811 -0.860 _ALGMSESLFK(gl)R_
DNA2 Ubiquitylation K589 -1.040 _LMENTFVSK(gl)K_
DNA2 Ubiquitylation K590 -1.040 _LMENTFVSK(gl)K_

Background Information for DNA2:


Pubmed-DNA2 »
Uniprot-DNA2 »
Biogrid-DNA2 »
ProteomicsDB-DNA2 »

Tumorportal-DNA2 »
COSMIC-DNA2 »
GenomeRNAi-DNA2 »
Genecards-DNA2


Protein-protein Interactions for DNA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DNA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83


Protein complexes (CORUM database) featuring DNA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DNA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members GO Category GO:0042645 mitochondrial nucleoid Database 0.61
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members Pathway Pathway_340 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND 0 0.24
Category members Pathway Pathway_311 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 0 0.2
Category members GO Category GO:0043139 5'-3' DNA helicase activity Database 0.17
Category members GO Category GO:0043504 mitochondrial DNA repair Database 0.17
Category members Pathway Pathway_316 REACTOME_LAGGING_STRAND_SYNTHESIS 0 0.11
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members Disease phenotype Primordial_Dwarfism Primordial Dwarfism Database 0
Category members Disease phenotype PROGRESSIVE_EXTERNAL_OPHTHALMOPLEGIA_WITH_MITOCHONDRIAL_DNA_DELETIONS PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS Database 0
Category members GO Category GO:0000076 DNA replication checkpoint Database 0
Category members GO Category GO:0000729 DNA double-strand break processing Database 0
Category members GO Category GO:0005760 gamma DNA polymerase complex Database 0
Category members GO Category GO:0006264 mitochondrial DNA replication Database 0
Category members GO Category GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base Database 0
Category members GO Category GO:0017108 5'-flap endonuclease activity Database 0
Category members GO Category GO:0043137 DNA replication, removal of RNA primer Database 0
Category members GO Category GO:0043142 single-stranded DNA-dependent ATPase activity Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0


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