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Query: DDX1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DDX1 0 1.686 -0.100 0.160 -0.034 -0.036 0.487 -0.133 0.258

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DDX1 Phosphorylation S481 0.023 0.050 _DNTRPGANS(ph)PEMWSEAIK_
DDX1 Ubiquitylation K82 -0.137 _TTIK(gl)TGASVLNK_
DDX1 Ubiquitylation K117 1.370 _EVK(gl)EWHGCR_
DDX1 Ubiquitylation K173 1.499 _FGFGFGGTGKK(gl)_
DDX1 Ubiquitylation K260 -0.585 _DGFVALSK(gl)APDGYIVK_
DDX1 Ubiquitylation K281 0.294 _SQHSGNAQVTQTK(gl)FLPNAPK_
DDX1 Ubiquitylation K358 1.293 _LDDLVSTGK(gl)LNLSQVR_

Background Information for DDX1:


Pubmed-DDX1 »
Uniprot-DDX1 »
Biogrid-DDX1 »
ProteomicsDB-DDX1 »

Tumorportal-DDX1 »
COSMIC-DDX1 »
GenomeRNAi-DDX1 »
Genecards-DDX1


Protein-protein Interactions for DDX1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UXS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DDX1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members RNA_helicase_DEAD_Q_motif IPR014014 0.24
Category members B30.2/SPRY IPR001870 0
Category members SPRY_dom IPR003877 0
Category members ConA-like_lec_gl_sf IPR008985 0


Protein complexes (CORUM database) featuring DDX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1332 Large Drosha complex Database 0.08


Categories featuring DDX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0010494 cytoplasmic stress granule Database 1.32
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0008143 poly(A) RNA binding Database 0.44
Category members GO Category GO:0000245 spliceosomal complex assembly Database 0.39
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0003724 RNA helicase activity Database 0.07
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04
Category members GO Category GO:0004527 exonuclease activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0043330 response to exogenous dsRNA Database 0


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