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Query: CUL3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CUL3 2 2.215 2.600 -1.300 0.182 -0.454 0.077 -0.259 -0.135

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CUL3 Ubiquitylation K292 1.094 0.852 _NGK(gl)TEDLGCMYK_
CUL3 Ubiquitylation K459 0.752 _LK(gl)TECGCQFTSK_
CUL3 Ubiquitylation K236 1.952 0.663 _FLAENSASVYIKK(gl)_
CUL3 Ubiquitylation K262 -0.525 -0.203 _STEEPIVK(gl)VVER_
CUL3 Ubiquitylation K6 -0.611 _(ac)SNLSK(gl)GTGSR_
CUL3 Ubiquitylation K680 -1.024 _IQTVAAK(gl)QGESDPERK_

Background Information for CUL3:


Pubmed-CUL3 »
Uniprot-CUL3 »
Biogrid-CUL3 »
ProteomicsDB-CUL3 »

Tumorportal-CUL3 »
COSMIC-CUL3 »
GenomeRNAi-CUL3 »
Genecards-CUL3


Protein-protein Interactions for CUL3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CUL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BTBD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS7B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCTD13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCTD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCTD9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL36 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC42 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF444 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CUL3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cullin_homology IPR016158 1.15
Category members Cullin_N IPR001373 0.9
Category members Cullin_neddylation_domain IPR019559 0.68
Category members Cullin_repeat-like_dom IPR016159 0.66


Protein complexes (CORUM database) featuring CUL3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2715 Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) Database 0.61
Category members Corum 1225 Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) Database 0.08
Category members Corum 222 CAND1-CUL3-RBX1 complex Database 0.06
Category members Corum 1243 Ubiquitin E3 ligase (SPOP, DAXX, CUL3) Database 0.04
Category members Corum 1224 Ubiquitin E3 ligase (BMI1, SPOP, CUL3) Database 0


Categories featuring CUL3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0040016 embryonic cleavage Database 1.36
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0031461 cullin-RING ubiquitin ligase complex Database 0.77
Category members Pathway Pathway_671 PID_WNT_CANONICAL_PATHWAY 0 0.64
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0000090 mitotic anaphase Database 0.47
Category members GO Category GO:0032467 positive regulation of cytokinesis Database 0.35
Category members GO Category GO:0006888 ER to Golgi vesicle-mediated transport Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0035024 negative regulation of Rho protein signal transduction Database 0.06
Category members GO Category GO:0031208 POZ domain binding Database 0.05
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0001831 trophectodermal cellular morphogenesis Database 0
Category members GO Category GO:0005827 polar microtubule Database 0
Category members GO Category GO:0006513 protein monoubiquitination Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0008054 cyclin catabolic process Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0017145 stem cell division Database 0
Category members GO Category GO:0030332 cyclin binding Database 0
Category members GO Category GO:0031463 Cul3-RING ubiquitin ligase complex Database 0
Category members GO Category GO:0043149 stress fiber assembly Database 0
Category members GO Category GO:0048208 COPII vesicle coating Database 0
Category members GO Category GO:0051322 anaphase Database 0


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