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Query: CPSF3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CPSF3 0 1.072 0.760 -0.720 -0.001 -0.206 0.455 -0.433 0.066

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CPSF3 Ubiquitylation K428 0.656 0.535 _LK(gl)AALIR_
CPSF3 Ubiquitylation K487 0.072 0.155 _VSGILVK(gl)R_
CPSF3 Ubiquitylation K348 0.384 _ELFESWCTDK(gl)R_
CPSF3 Ubiquitylation K465 0.422 _NTEAVTLNFRGEKLAK(gl)_
CPSF3 Ubiquitylation K474 -0.536 _VMGFLADKK(gl)PEQGQR_
CPSF3 Ubiquitylation K604 -0.159 _K(gl)LEMHVYSK_

Background Information for CPSF3:


Pubmed-CPSF3 »
Uniprot-CPSF3 »
Biogrid-CPSF3 »
ProteomicsDB-CPSF3 »

Tumorportal-CPSF3 »
COSMIC-CPSF3 »
GenomeRNAi-CPSF3 »
Genecards-CPSF3


Protein-protein Interactions for CPSF3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CPSF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait FIP1L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KDM1B Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21B Cat. description Hein, Mann, Cell 2015
Category members IP bait SYMPK Cat. description Hein, Mann, Cell 2015
Category members IP bait CPSF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPSF4L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2CBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CPSF3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Beta-lactamas-like IPR001279 0
Category members RMMBL IPR011108 0
Category members Beta_Casp IPR022712 0


Protein complexes (CORUM database) featuring CPSF3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 1144 Cleavage and polyadenylation factor (CPSF) Database 0.01
Category members Corum 1147 Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3) Database 0


Categories featuring CPSF3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members Pathway Pathway_878 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 0 6.53
Category members Pathway Pathway_886 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT 0 5.93
Category members GO Category GO:0006406 mRNA export from nucleus Database 4.09
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members Pathway Pathway_852 REACTOME_MRNA_3_END_PROCESSING 0 2.02
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_854 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 0 0.91
Category members GO Category GO:0031124 mRNA 3'-end processing Database 0.91
Category members GO Category GO:0006369 termination of RNA polymerase II transcription Database 0.87
Category members Pathway Pathway_855 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS 0 0.29
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0008409 5'-3' exonuclease activity Database 0.13
Category members GO Category GO:0005847 mRNA cleavage and polyadenylation specificity factor complex Database 0.11
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1
Category members Pathway Pathway_853 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA 0 0.05
Category members GO Category GO:0004521 endoribonuclease activity Database 0
Category members GO Category GO:0006379 mRNA cleavage Database 0
Category members GO Category GO:0006398 histone mRNA 3'-end processing Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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