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Query: CEP290

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CEP290 1 0.626 1.020 -0.690
CEP290 1 0.626 2.010 -1.090

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CEP290 Ubiquitylation K593 -1.125 _K(gl)LDLLSLK_
CEP290 Ubiquitylation K735 -1.199 _KEAINYSQQLAK(gl)ANLK_
CEP290 Ubiquitylation K830 0.626 _EYLSEK(gl)ETWK_
CEP290 Ubiquitylation K1178 -1.408 _DK(gl)EVESLR_
CEP290 Ubiquitylation K1336 -0.794 _GLEELISTLK(gl)DTK_
CEP290 Ubiquitylation K1552 -0.135 _LNQK(gl)EEVLKK_
CEP290 Ubiquitylation K1682 0.578 _LQLQENHEDEVKK(gl)_

Background Information for CEP290:


Pubmed-CEP290 »
Uniprot-CEP290 »
Biogrid-CEP290 »
ProteomicsDB-CEP290 »

Tumorportal-CEP290 »
COSMIC-CEP290 »
GenomeRNAi-CEP290 »
Genecards-CEP290


Protein-protein Interactions for CEP290
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC14 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP135 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP290 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA3 Cat. description Hein, Mann, Cell 2015
Category members IP bait LGALS3BP Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTNBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IQCB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LZTS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PEG10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CEP290
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring CEP290
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CEP290
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members Disease phenotype Leber_congenital_amaurosis Leber congenital amaurosis Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Disease phenotype Joubert_syndrome_with_oculorenal_defect Joubert syndrome with oculorenal defect Database 0.03
Category members Disease phenotype Senior-Loken_syndrome Senior-Loken syndrome Database 0.02
Category members GO Category GO:0030902 hindbrain development Database 0.02
Category members Disease phenotype BARDET-BIEDL_SYNDROME BARDET-BIEDL SYNDROME Database 0
Category members Disease phenotype Meckel_syndrome Meckel syndrome Database 0
Category members GO Category GO:0000930 gamma-tubulin complex Database 0
Category members GO Category GO:0005932 microtubule basal body Database 0
Category members GO Category GO:0030814 regulation of cAMP metabolic process Database 0
Category members GO Category GO:0030916 otic vesicle formation Database 0
Category members GO Category GO:0032391 photoreceptor connecting cilium Database 0
Category members GO Category GO:0036038 TCTN-B9D complex Database 0
Category members GO Category GO:0042384 cilium assembly Database 0
Category members GO Category GO:0042462 eye photoreceptor cell development Database 0
Category members GO Category GO:0048793 pronephros development Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0
Category members GO Category GO:0060271 cilium morphogenesis Database 0


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