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Query: CDC73

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDC73 1 2.517 1.000 -0.660 1.109 0.620 1.610 -0.862 0.436

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDC73 Ubiquitylation K209 -0.003 -1.671 _TDLDDDITALK(gl)QR_
CDC73 Ubiquitylation K136 0.034 _AADEVLAEAK(gl)KPR_
CDC73 Ubiquitylation K161 1.275 _LEGHK(gl)EGIVQTEQIR_
CDC73 Ubiquitylation K198 0.681 _STIK(gl)TDLDDDITALK_
CDC73 Ubiquitylation K243 0.937 _TTILQSTGK(gl)NFSK_
CDC73 Ubiquitylation K247 0.739 _TTILQSTGKNFSK(gl)_
CDC73 Ubiquitylation K283 -0.189 _TK(gl)QPIPAAYNR_

Background Information for CDC73:


Pubmed-CDC73 »
Uniprot-CDC73 »
Biogrid-CDC73 »
ProteomicsDB-CDC73 »

Tumorportal-CDC73 »
COSMIC-CDC73 »
GenomeRNAi-CDC73 »
Genecards-CDC73


Protein-protein Interactions for CDC73
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP4S1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD44 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC73 Cat. description Hein, Mann, Cell 2015
Category members IP bait CNTROB Cat. description Hein, Mann, Cell 2015
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait LEO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2G Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait RFX5 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPRD1B Cat. description Hein, Mann, Cell 2015
Category members IP bait SUPT5H Cat. description Hein, Mann, Cell 2015
Category members IP bait TOX4 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR61 Cat. description Hein, Mann, Cell 2015
Category members IP bait ERMAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TULP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDC73
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring CDC73
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1167 Paf complex Database 1.75


Categories featuring CDC73
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0001711 endodermal cell fate commitment Database 2.34
Category members GO Category GO:0016593 Cdc73/Paf1 complex Database 1.75
Category members GO Category GO:0010390 histone monoubiquitination Database 1.39
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter Database 0.99
Category members GO Category GO:0000993 RNA polymerase II core binding Database 0.91
Category members GO Category GO:0033523 histone H2B ubiquitination Database 0.77
Category members GO Category GO:0031442 positive regulation of mRNA 3'-end processing Database 0.7
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0045638 negative regulation of myeloid cell differentiation Database 0.1
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Disease phenotype Familial_isolated_hyperparathyroidism Familial isolated hyperparathyroidism Database 0
Category members Disease phenotype Familial_parathyroid_adenoma Familial parathyroid adenoma Database 0
Category members Disease phenotype HYPERPARATHYROIDISM_1 HYPERPARATHYROIDISM 1 Database 0
Category members GO Category GO:0030177 positive regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0031648 protein destabilization Database 0
Category members GO Category GO:0048147 negative regulation of fibroblast proliferation Database 0
Category members GO Category GO:0071222 cellular response to lipopolysaccharide Database 0


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