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Query: CASK

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CASK 1 1.722 2.050 -1.110
CASK 1 1.722 2.050 -1.110 -0.162 -0.217 -0.918 0.048 0.372

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CASK Ubiquitylation K41 1.029 1.231 _ETGQQFAVK(gl)IVDVAK_
CASK Ubiquitylation K60 0.240 0.541 _FTSSPGLSTEDLK(gl)R_
CASK Phosphorylation S570 0.125 _TQSS(ph)SCEDLPSTTQPK_
CASK Phosphorylation S571 0.134 -0.032 _TQSSS(ph)CEDLPSTTQPK_
CASK Ubiquitylation K665 -0.631 _LENSK(gl)NGTAGLIPSPELQEWR_
CASK Ubiquitylation K691 1.108 _TK(gl)QEQQASCTWFGK_
CASK Ubiquitylation K703 0.627 _TKQEQQASCTWFGK(gl)K_
CASK Ubiquitylation K704 0.627 _TKQEQQASCTWFGK(gl)K_

Background Information for CASK:


Pubmed-CASK »
Uniprot-CASK »
Biogrid-CASK »
ProteomicsDB-CASK »

Tumorportal-CASK »
COSMIC-CASK »
GenomeRNAi-CASK »
Genecards-CASK


Protein-protein Interactions for CASK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF26B Cat. description Hein, Mann, Cell 2015
Category members IP bait LIN7C Cat. description Hein, Mann, Cell 2015
Category members IP bait PXDC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC16A6 Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIM26 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIN7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYBPHL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF414 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CASK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members L27 IPR004172 1.84
Category members GK/Ca_channel_bsu IPR008145 1.36
Category members Guanylate_kin-like IPR008144 1.32
Category members L27_C IPR014775 0.33
Category members PDZ IPR001478 0.15
Category members SH3_2 IPR011511 0.08
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members SH3_domain IPR001452 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CASK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3207 LIN2-LIN7-SAP97-MINT1 complex Database 0
Category members Corum 3208 LIN2-LIN7 complex Database 0
Category members Corum 617 CASK-LIN7C-APBA1 complex Database 0


Categories featuring CASK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0004385 guanylate kinase activity Database 1.77
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005652 nuclear lamina Database 1.08
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_1074 PID_SYNDECAN_3_PATHWAY 0 0.65
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_476 PID_SYNDECAN_1_PATHWAY 0 0
Category members GO Category GO:0001953 negative regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0010839 negative regulation of keratinocyte proliferation Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0042043 neurexin family protein binding Database 0
Category members GO Category GO:0042734 presynaptic membrane Database 0
Category members GO Category GO:0060170 ciliary membrane Database 0
Category members GO Category GO:0061045 negative regulation of wound healing Database 0
Category members GO Category GO:0070509 calcium ion import Database 0


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