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Query: BRD4

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BRD4 2 6.192 -0.320 0.280 0.080 0.220 0.614 0.191 0.117

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BRD4 Phosphorylation S1117 2.833 1.857 _IHS(ph)PIIR_
BRD4 Phosphorylation S1126 1.336 0.890 _SEPFS(ph)PSLRPEPPKHPESIK_
BRD4 Phosphorylation S470 -0.308 -0.758 _MPDEPEEPVVAVSS(ph)PAVPPPTK_
BRD4 Phosphorylation S469 -0.308 -1.544 _MPDEPEEPVVAVS(ph)SPAVPPPTK_
BRD4 Phosphorylation S1083 -1.699 -1.783 _EAPSPLMIHSPQMSQFQSLTHQS(ph)PPQQNVQPK_

Background Information for BRD4:


Pubmed-BRD4 »
Uniprot-BRD4 »
Biogrid-BRD4 »
ProteomicsDB-BRD4 »

Tumorportal-BRD4 »
COSMIC-BRD4 »
GenomeRNAi-BRD4 »
Genecards-BRD4


Protein-protein Interactions for BRD4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM90A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPSM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JMJD6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BRD4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Bromodomain IPR001487 1.43


Protein complexes (CORUM database) featuring BRD4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2601 P-TEFb-BRD4-TRAP220 complex Database 1.23
Category members Corum 2875 BRD4-P-TEFb complex Database 0.7
Category members Corum 2877 BRD4-P-TEFb complex Database 0.7
Category members Corum 2600 BRD4 complex Database 0.63
Category members Corum 2203 BRD4-RFC complex Database 0


Categories featuring BRD4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter Database 0.99
Category members GO Category GO:0070577 histone acetyl-lysine binding Database 0.88
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members GO Category GO:0043983 histone H4-K12 acetylation Database 0.16
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0010971 positive regulation of G2/M transition of mitotic cell cycle Database 0.07
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0001833 inner cell mass cell proliferation Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043388 positive regulation of DNA binding Database 0
Category members GO Category GO:0044154 histone H3-K14 acetylation Database 0
Category members GO Category GO:0050727 regulation of inflammatory response Database 0


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