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Query: APH1B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APH1B 1 2.922 -1.760 3.070

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
APH1B Ubiquitylation K102 -0.148 _ASEGLK(gl)SINPGETAPSMR_

Background Information for APH1B:


Pubmed-APH1B »
Uniprot-APH1B »
Biogrid-APH1B »
ProteomicsDB-APH1B »

Tumorportal-APH1B »
COSMIC-APH1B »
GenomeRNAi-APH1B »
Genecards-APH1B


Protein-protein Interactions for APH1B
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in APH1B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members MFS_dom_general_subst_transpt IPR016196 0


Protein complexes (CORUM database) featuring APH1B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3128 Gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN) Database 0.18
Category members Corum 467 Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) Database 0.18


Categories featuring APH1B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members Pathway Pathway_1074 PID_SYNDECAN_3_PATHWAY 0 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0016485 protein processing Database 0.57
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_1159 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR 0 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_1278 REACTOME_SIGNALING_BY_NOTCH2 0 0
Category members Pathway Pathway_1279 REACTOME_SIGNALING_BY_NOTCH3 0 0
Category members Pathway Pathway_1280 REACTOME_SIGNALING_BY_NOTCH4 0 0
Category members Pathway Pathway_799 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0030133 transport vesicle Database 0
Category members GO Category GO:0031293 membrane protein intracellular domain proteolysis Database 0


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