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Query: AP3S1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AP3S1 0 -0.755 1.210 -1.210 -1.064 -0.141

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AP3S1 Ubiquitylation K18 -0.109 0.558 _LSK(gl)FYQPYSEDTQQQIIR_
AP3S1 Ubiquitylation K166 -0.248 _AVSAVK(gl)NMNLPEIPR_
AP3S1 Ubiquitylation K193 -0.977 _VPNLPSFK(gl)_

Background Information for AP3S1:


Pubmed-AP3S1 »
Uniprot-AP3S1 »
Biogrid-AP3S1 »
ProteomicsDB-AP3S1 »

Tumorportal-AP3S1 »
COSMIC-AP3S1 »
GenomeRNAi-AP3S1 »
Genecards-AP3S1


Protein-protein Interactions for AP3S1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CD14 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1107 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF4A Cat. description Hein, Mann, Cell 2015
Category members IP bait MAST3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCDHB15 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZWINT Cat. description Hein, Mann, Cell 2015
Category members IP bait AP3S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DTNBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ICAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IGSF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IRGC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLK11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MUC20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PMEL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM63A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AP3S1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Longin-like_dom IPR011012 0.34
Category members AP_complex_ssu IPR016635 0.31
Category members AP_mu_sigma_su IPR022775 0.25


Protein complexes (CORUM database) featuring AP3S1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 59 AP3 adapter complex Database 0.58
Category members Corum 2308 AP3D1-AP3S1 complex Database 0.24
Category members Corum 652 AP3-BLOC1 complex Database 0


Categories featuring AP3S1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0008565 protein transporter activity Database 0.26
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0030123 AP-3 adaptor complex Database 0.05
Category members GO Category GO:0030119 AP-type membrane coat adaptor complex Database 0.03
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0008089 anterograde axon cargo transport Database 0
Category members GO Category GO:0030117 membrane coat Database 0
Category members GO Category GO:0030133 transport vesicle Database 0
Category members GO Category GO:0048490 anterograde synaptic vesicle transport Database 0


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