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Query: ANK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ANK2 0 1.365 0.370 -0.920

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ANK2 Phosphorylation S1461 0.678 0.687 _ESES(ph)DQEQEEEIDMTSEK_
ANK2 Phosphorylation S1459 0.673 0.675 _ES(ph)ESDQEQEEEIDM(ox)TSEK_
ANK2 Phosphorylation T3844 0.389 _T(ph)SLVIVESADNQPETCER_
ANK2 Phosphorylation S3845 0.659 0.389 _KTS(ph)LVIVESADNQPETCER_
ANK2 Phosphorylation S3793 0.342 0.385 _AMIVPSS(ph)PSK_
ANK2 Phosphorylation S3823 -0.465 -0.203 _GGS(ph)PIIQEPEEPSEHREESSPR_

Background Information for ANK2:


Pubmed-ANK2 »
Uniprot-ANK2 »
Biogrid-ANK2 »
ProteomicsDB-ANK2 »

Tumorportal-ANK2 »
COSMIC-ANK2 »
GenomeRNAi-ANK2 »
Genecards-ANK2


Protein-protein Interactions for ANK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C14orf104 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGUOK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1AN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK8IP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUFIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PALM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAPGEF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ANK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DEATH-like_dom IPR011029 1.15
Category members Death_domain IPR000488 0.08
Category members ZU5_dom IPR000906 0
Category members Ankyrin_rpt IPR002110 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring ANK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ANK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0043034 costamere Database 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0030507 spectrin binding Database 1.12
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0043268 positive regulation of potassium ion transport Database 0.44
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members GO Category GO:0031647 regulation of protein stability Database 0.21
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0051924 regulation of calcium ion transport Database 0.11
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0070972 protein localization to endoplasmic reticulum Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Disease phenotype Romano-Ward_syndrome Romano-Ward syndrome Database 0
Category members GO Category GO:0002027 regulation of heart rate Database 0
Category members GO Category GO:0003283 atrial septum development Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Database 0
Category members GO Category GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling Database 0
Category members GO Category GO:0015459 potassium channel regulator activity Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0030315 T-tubule Database 0
Category members GO Category GO:0030913 paranodal junction assembly Database 0
Category members GO Category GO:0031430 M band Database 0
Category members GO Category GO:0031672 A band Database 0
Category members GO Category GO:0033292 T-tubule organization Database 0
Category members GO Category GO:0033365 protein localization to organelle Database 0
Category members GO Category GO:0034394 protein localization to cell surface Database 0
Category members GO Category GO:0036309 protein localization to M-band Database 0
Category members GO Category GO:0051117 ATPase binding Database 0
Category members GO Category GO:0051279 regulation of release of sequestered calcium ion into cytosol Database 0
Category members GO Category GO:0051597 response to methylmercury Database 0
Category members GO Category GO:0051928 positive regulation of calcium ion transport Database 0
Category members GO Category GO:0055117 regulation of cardiac muscle contraction Database 0
Category members GO Category GO:0060048 cardiac muscle contraction Database 0
Category members GO Category GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization Database 0
Category members GO Category GO:0070296 sarcoplasmic reticulum calcium ion transport Database 0


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