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Query: ZIC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ZIC2 0 -0.323 0.440 -0.440

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ZIC2 Ubiquitylation K253 -0.697 0.374 _QQCIK(gl)QELICK_

Background Information for ZIC2:


Pubmed-ZIC2 »
Uniprot-ZIC2 »
Biogrid-ZIC2 »
ProteomicsDB-ZIC2 »

Tumorportal-ZIC2 »
COSMIC-ZIC2 »
GenomeRNAi-ZIC2 »
Genecards-ZIC2


Protein-protein Interactions for ZIC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AHCYL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAGK Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ZIC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92


Protein complexes (CORUM database) featuring ZIC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ZIC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0048066 developmental pigmentation Database 0.15
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members Disease phenotype Alobar_holoprosencephaly Alobar holoprosencephaly Database 0
Category members Disease phenotype Holoprosencephaly Holoprosencephaly Database 0
Category members Disease phenotype Lobar_holoprosencephaly Lobar holoprosencephaly Database 0
Category members Disease phenotype Microform_holoprosencephaly Microform holoprosencephaly Database 0
Category members Disease phenotype Midline_interhemispheric_variant_of_holoprosencephaly Midline interhemispheric variant of holoprosencephaly Database 0
Category members Disease phenotype Semilobar_holoprosencephaly Semilobar holoprosencephaly Database 0
Category members Disease phenotype Septopreoptic_holoprosencephaly Septopreoptic holoprosencephaly Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007601 visual perception Database 0
Category members GO Category GO:0031290 retinal ganglion cell axon guidance Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0


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