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Query: UBE3A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
UBE3A 2 8.983 -0.310 -0.470

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
UBE3A Phosphorylation S218 3.592 3.254 _IGDSS(ph)QGDNNLQK_
UBE3A Ubiquitylation K373 1.085 1.052 _NLVNDDDAIVAASK(gl)CLK_
UBE3A Ubiquitylation K77 0.131 0.538 _ALELYK(gl)INAK_
UBE3A Ubiquitylation K824 0.226 _LK(gl)MIIAK_
UBE3A Ubiquitylation K552 -0.235 0.125 _LEMIAMENPADLK(gl)K_
UBE3A Ubiquitylation K553 -0.235 0.125 _LEMIAMENPADLK(gl)K_
UBE3A Ubiquitylation K315 -0.507 _AMSK(gl)LPLAAQGK_
UBE3A Ubiquitylation K323 -0.547 _LPLAAQGK(gl)LIR_
UBE3A Ubiquitylation K89 -0.782 _LCDPHPSK(gl)K_
UBE3A Ubiquitylation K90 -0.804 _LCDPHPSKK(gl)_
UBE3A Ubiquitylation K112 -0.670 _GAPNNSCSEIK(gl)MNKK_
UBE3A Ubiquitylation K123 0.184 _IDFK(gl)DVTYLTEEK_

Background Information for UBE3A:


Pubmed-UBE3A »
Uniprot-UBE3A »
Biogrid-UBE3A »
ProteomicsDB-UBE3A »

Tumorportal-UBE3A »
COSMIC-UBE3A »
GenomeRNAi-UBE3A »
Genecards-UBE3A


Protein-protein Interactions for UBE3A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PSMB5 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMD14 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMD6 Cat. description Hein, Mann, Cell 2015
Category members IP bait CELA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS7B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM167A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1AN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KDELR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAP7D2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSUN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLAUR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPH3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRPRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPV5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UCHL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in UBE3A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HECT IPR000569 0.04


Protein complexes (CORUM database) featuring UBE3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5209 Ubiquilin-proteasome complex Database 0.04


Categories featuring UBE3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0000502 proteasome complex Database 3.17
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members Pathway Pathway_467 BIOCARTA_PROTEASOME_PATHWAY 0 0.82
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members Disease phenotype ANGELMAN_SYNDROME ANGELMAN SYNDROME Database 0.04
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0060736 prostate gland growth Database 0
Category members GO Category GO:0070936 protein K48-linked ubiquitination Database 0


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