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Query: TRIM28

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TRIM28 4 8.458 -0.250 -0.030
TRIM28 4 8.458 -0.250 -0.030 -0.451 -1.012 0.467 -0.209 -0.279

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TRIM28 Ubiquitylation K779 0.334 2.706 _LTEDK(gl)ADVQSIIGLQR_
TRIM28 Phosphorylation S473 3.049 2.476 _S(ph)GEGEVSGLMR_
TRIM28 Phosphorylation S471 3.215 2.215 _S(ph)RSGEGEVSGLM(ox)R_
TRIM28 Phosphorylation S681 1.735 _EEDGS(ph)LSLDGADSTGVVAK_
TRIM28 Phosphorylation T541 3.001 1.292 _GAAAAATGQPGTAPAGT(ph)PGAPPLAGMAIVK_
TRIM28 Phosphorylation S594 1.033 _LAS(ph)PSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICR_
TRIM28 Ubiquitylation K261 1.520 0.923 _LLASLVK(gl)R_
TRIM28 Phosphorylation S752 0.314 0.567 _LQEKLS(ph)PPYSSPQEFAQDVGR_
TRIM28 Ubiquitylation K319 0.332 0.451 _VLVNDAQK(gl)VTEGQQER_
TRIM28 Ubiquitylation K254 0.323 0.381 _K(gl)LLASLVK_
TRIM28 Phosphorylation S41 0.373 _RSTAPSAAAS(ph)ASASAAASSPAGGGAEALELLEHCGVCR_
TRIM28 Ubiquitylation K770 0.289 _MFK(gl)QFNK_
TRIM28 Phosphorylation T498 0.265 _VSLERLDLDLT(ph)ADSQPPVFK_
TRIM28 Phosphorylation S26 0.197 _(ac)AASAAAASAAAASAASGSPGPGEGS(ph)AGGEK_
TRIM28 Phosphorylation S50 -0.113 0.075 _RSTAPSAAASASASAAASS(ph)PAGGGAEALELLEHCGVCR_
TRIM28 Phosphorylation S489 0.264 0.043 _VS(ph)LERLDLDLTADSQPPVFK_
TRIM28 Ubiquitylation K266 0.465 -0.005 _LGDK(gl)HATLQK_
TRIM28 Phosphorylation S17 -0.227 -0.026 _(ac)AASAAAASAAAASAAS(ph)GSPGPGEGSAGGEK_
TRIM28 Ubiquitylation K272 1.576 -0.085 _LGDKHATLQK(gl)STK_
TRIM28 Ubiquitylation K340 0.112 -0.105 _IQK(gl)HQEHILR_
TRIM28 Phosphorylation S49 -0.388 -0.110 _STAPSAAASASASAAAS(ph)SPAGGGAEALELLEHCGVCR_
TRIM28 Phosphorylation S19 -0.068 -0.189 _(ac)AASAAAASAAAASAASGS(ph)PGPGEGSAGGEK_
TRIM28 Phosphorylation S4 -0.337 _(ac)AAS(ph)AAAASAAAASAASGSPGPGEGSAGGEK_
TRIM28 Phosphorylation S624 -1.117 _LASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDS(ph)ATICR_
TRIM28 Ubiquitylation K337 0.976 _QHWTM(ox)TK(gl)IQK_
TRIM28 Ubiquitylation K407 -2.105 _SAEAFGK(gl)IVAERPGTNSTGPAPMAPPR_
TRIM28 Phosphorylation S14 -0.154 _(ac)AASAAAASAAAAS(ph)AASGSPGPGEGSAGGEK_
TRIM28 Phosphorylation S43 0.010 _RSTAPSAAASAS(ph)ASAAASSPAGGGAEALELLEHCGVCR_
TRIM28 Phosphorylation S756 -0.408 _LSPPYS(ph)SPQEFAQDVGR_

Background Information for TRIM28:


Pubmed-TRIM28 »
Uniprot-TRIM28 »
Biogrid-TRIM28 »
ProteomicsDB-TRIM28 »

Tumorportal-TRIM28 »
COSMIC-TRIM28 »
GenomeRNAi-TRIM28 »
Genecards-TRIM28


Protein-protein Interactions for TRIM28
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GDI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IPO8 Cat. description Hein, Mann, Cell 2015
Category members IP bait L1TD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SET Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF673 Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIM28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZIM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF223 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF250 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF254 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF264 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF274 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF324B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF331 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF354C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF416 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF517 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF621 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF669 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF695 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF707 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF747 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF764 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF829 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TRIM28
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Bromodomain IPR001487 1.43
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_PHD IPR001965 1.15
Category members Znf_PHD-finger IPR019787 0.91
Category members Bbox_C IPR003649 0.18
Category members Znf_B-box IPR000315 0
Category members Znf_RING IPR001841 0


Protein complexes (CORUM database) featuring TRIM28
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5614 Emerin complex 32 Database 1.48
Category members Corum 1413 NCOR1 complex Database 0.65


Categories featuring TRIM28
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0005720 nuclear heterochromatin Database 1.41
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0070087 chromo shadow domain binding Database 1.14
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0016925 protein sumoylation Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0005719 nuclear euchromatin Database 0.15
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0001837 epithelial to mesenchymal transition Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0042993 positive regulation of transcription factor import into nucleus Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0060028 convergent extension involved in axis elongation Database 0
Category members GO Category GO:0060669 embryonic placenta morphogenesis Database 0


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