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Query: TOP2B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TOP2B 1 5.187 0.830 -0.650 -1.137 0.859 0.666

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TOP2B Phosphorylation S1454 1.291 _KSQDFGNLFSFPSYS(ph)QK_
TOP2B Ubiquitylation K1079 0.700 _FILEK(gl)IQGK_
TOP2B Ubiquitylation K550 0.643 _SYDDAESLK(gl)TLR_
TOP2B Ubiquitylation K205 0.226 _FTVETACK(gl)EYK_
TOP2B Ubiquitylation K646 0.051 _EAK(gl)EYFADMER_
TOP2B Ubiquitylation K643 -0.133 _GLGTSTAK(gl)EAK_
TOP2B Phosphorylation T1403 -0.017 -0.156 _VKASPIT(ph)NDGEDEFVPSDGLDKDEYTFSPGK_
TOP2B Ubiquitylation K221 -0.165 _QTWMNNMMK(gl)TSEAK_
TOP2B Ubiquitylation K676 -0.188 _YAGPEDDAAITLAFSK(gl)K_
TOP2B Ubiquitylation K677 -0.188 _YAGPEDDAAITLAFSK(gl)K_
TOP2B Phosphorylation S1400 -0.221 -0.192 _VKAS(ph)PITNDGEDEFVPSDGLDKDEYTFSPGK_
TOP2B Phosphorylation S1466 -0.324 -0.202 _FDS(ph)NEEDSASVFSPSFGLK_
TOP2B Ubiquitylation K412 -0.274 _SFGSK(gl)CQLSEK_
TOP2B Ubiquitylation K373 -0.347 _AGVSVK(gl)PFQVK_
TOP2B Ubiquitylation K1227 -0.462 _K(gl)LQLEETMPSPYGR_
TOP2B Phosphorylation S1413 -0.430 -0.661 _ASPITNDGEDEFVPS(ph)DGLDKDEYTFSPGK_
TOP2B Ubiquitylation K1250 -0.673 _RIIPEITAM(ox)K(gl)ADASK_
TOP2B Phosphorylation S1581 -0.797 -1.005 _KTSFDQDS(ph)DVDIFPSDFPTEPPSLPR_
TOP2B Phosphorylation S1424 -1.672 -1.441 _ASPITNDGEDEFVPSDGLDKDEYTFS(ph)PGK_
TOP2B Phosphorylation T1422 -0.362 _VKAS(ph)PITNDGEDEFVPSDGLDKDEYT(ph)FSPGK_
TOP2B Phosphorylation S1552 2.808 _ASGS(ph)ENEGDYNPGRK_

Background Information for TOP2B:


Pubmed-TOP2B »
Uniprot-TOP2B »
Biogrid-TOP2B »
ProteomicsDB-TOP2B »

Tumorportal-TOP2B »
COSMIC-TOP2B »
GenomeRNAi-TOP2B »
Genecards-TOP2B


Protein-protein Interactions for TOP2B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATRX Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DAXX Cat. description Hein, Mann, Cell 2015
Category members IP bait EEF1A1;EEF1A1P5 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CUL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPATCH4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSD3B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLAUR Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TOP2B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HATPase_C IPR003594 1.07
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06
Category members TopoII_euk IPR001154 0.29
Category members Topo_IIA IPR001241 0.29
Category members Topo_IIA_A/C IPR002205 0.29
Category members DTHCT IPR012542 0.29
Category members Topo_IIA_bsu_dom2 IPR013506 0.29
Category members Topo_IIA_like_dom IPR013760 0.29


Protein complexes (CORUM database) featuring TOP2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1230 WINAC complex Database 3.79
Category members Corum 3135 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.58
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02
Category members Corum 1098 DNA synthesome complex (13 subunits) Database 0.35
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22


Categories featuring TOP2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members GO Category GO:0006265 DNA topological change Database 1.92
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_956 BIOCARTA_DNAFRAGMENT_PATHWAY 0 0.62
Category members GO Category GO:0006261 DNA-dependent DNA replication Database 0.48
Category members GO Category GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Database 0.39
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0000712 resolution of meiotic recombination intermediates Database 0.25
Category members GO Category GO:0000819 sister chromatid segregation Database 0.17
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0006312 mitotic recombination Database 0.14
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members GO Category GO:0000795 synaptonemal complex Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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