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Query: TONSL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TONSL 1 -0.168 -1.900 3.540 -0.261 -3.160 0.665 1.051

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TONSL Phosphorylation S719 -0.359 -0.212 _VS(ph)PGQAAPAMARPR_
TONSL Ubiquitylation K336 -1.432 _AAEAYQK(gl)QLR_

Background Information for TONSL:


Pubmed-TONSL »
Uniprot-TONSL »
Biogrid-TONSL »
ProteomicsDB-TONSL »

Tumorportal-TONSL »
COSMIC-TONSL »
GenomeRNAi-TONSL »
Genecards-TONSL


Protein-protein Interactions for TONSL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ASF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASF1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TONSL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR-contain_dom IPR013026 0.97
Category members TPR_repeat IPR019734 0.93
Category members Leu-rich_rpt_RNase_inh_sub-typ IPR003590 0.06
Category members Ankyrin_rpt IPR002110 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring TONSL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TONSL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0042555 MCM complex Database 1.41
Category members GO Category GO:0042393 histone binding Database 0.94
Category members Pathway Pathway_608 SIG_CD40PATHWAYMAP 0 0.89
Category members GO Category GO:0005662 DNA replication factor A complex Database 0.35
Category members GO Category GO:0043596 nuclear replication fork Database 0.23
Category members Pathway Pathway_514 ST_GAQ_PATHWAY 0 0.17
Category members GO Category GO:0042994 cytoplasmic sequestering of transcription factor Database 0.14
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_515 ST_B_CELL_ANTIGEN_RECEPTOR 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0031297 replication fork processing Database 0
Category members GO Category GO:0035101 FACT complex Database 0


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