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Query: TLK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TLK2 0 0.621 -0.170 -0.340 0.092

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TLK2 Phosphorylation T98 0.262 _ISDYFEFAGGSAPGT(ph)SPGR_
TLK2 Phosphorylation S99 0.267 -0.122 _ISDYFEFAGGSAPGTS(ph)PGR_

Background Information for TLK2:


Pubmed-TLK2 »
Uniprot-TLK2 »
Biogrid-TLK2 »
ProteomicsDB-TLK2 »

Tumorportal-TLK2 »
COSMIC-TLK2 »
GenomeRNAi-TLK2 »
Genecards-TLK2


Protein-protein Interactions for TLK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ASF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF13B Cat. description Hein, Mann, Cell 2015
Category members IP bait SMO Cat. description Hein, Mann, Cell 2015
Category members IP bait ASF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASF1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EID3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL1F6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LHX6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFPL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TLK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring TLK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TLK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0005882 intermediate filament Database 0
Category members GO Category GO:0010507 negative regulation of autophagy Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0


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