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Query: TK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TK1 0 -4.098 0.610 -0.460

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TK1 Phosphorylation S15 -1.567 -1.084 _SCINLPTVLPGSPS(ph)K_
TK1 Phosphorylation S13 -1.350 -1.354 _(ac)SCINLPTVLPGS(ph)PSK_
TK1 Ubiquitylation K16 -1.664 _(ac)SCINLPTVLPGSPSK(gl)TR_

Background Information for TK1:


Pubmed-TK1 »
Uniprot-TK1 »
Biogrid-TK1 »
ProteomicsDB-TK1 »

Tumorportal-TK1 »
COSMIC-TK1 »
GenomeRNAi-TK1 »
Genecards-TK1


Protein-protein Interactions for TK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LRRK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AGRP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDA2R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAMDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLA2G10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PM20D2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF202 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF232 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83


Protein complexes (CORUM database) featuring TK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0009165 nucleotide biosynthetic process Database 0.17
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_278 REACTOME_PYRIMIDINE_METABOLISM 0 0
Category members Pathway Pathway_77 KEGG_DRUG_METABOLISM_OTHER_ENZYMES 0 0
Category members GO Category GO:0006206 pyrimidine nucleobase metabolic process Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0019206 nucleoside kinase activity Database 0
Category members GO Category GO:0031667 response to nutrient levels Database 0
Category members GO Category GO:0043097 pyrimidine nucleoside salvage Database 0
Category members GO Category GO:0046688 response to copper ion Database 0
Category members GO Category GO:0048565 digestive tract development Database 0
Category members GO Category GO:0051414 response to cortisol Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0


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