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Query: TIMM50

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TIMM50 0 -1.433 0.710 -0.640 0.428 -0.608 -0.459 -1.171 -0.634

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TIMM50 Ubiquitylation K434 0.302 _LAELSK(gl)SNK_
TIMM50 Ubiquitylation K437 0.101 -0.071 _SNK(gl)QNLFLGSLTSR_
TIMM50 Ubiquitylation K353 -0.109 _VVVVDCK(gl)K_
TIMM50 Ubiquitylation K354 -0.109 _VVVVDCK(gl)K_
TIMM50 Ubiquitylation K167 -0.380 _AQGPQQQPGSEGPSYAK(gl)K_
TIMM50 Ubiquitylation K168 -0.380 _AQGPQQQPGSEGPSYAK(gl)K_

Background Information for TIMM50:


Pubmed-TIMM50 »
Uniprot-TIMM50 »
Biogrid-TIMM50 »
ProteomicsDB-TIMM50 »

Tumorportal-TIMM50 »
COSMIC-TIMM50 »
GenomeRNAi-TIMM50 »
Genecards-TIMM50


Protein-protein Interactions for TIMM50
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait SMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C20orf114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIMM50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZSCAN20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TIMM50
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NIF IPR004274 0.18
Category members HAD-like_dom IPR023214 0


Protein complexes (CORUM database) featuring TIMM50
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3098 TIM50a-SMN1 complex Database 0
Category members Corum 3099 TIM50a-coilin complex Database 0


Categories featuring TIMM50
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT 0 0.33
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0006626 protein targeting to mitochondrion Database 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members GO Category GO:0005134 interleukin-2 receptor binding Database 0.05
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0005744 mitochondrial inner membrane presequence translocase complex Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0007006 mitochondrial membrane organization Database 0
Category members GO Category GO:0035335 peptidyl-tyrosine dephosphorylation Database 0
Category members GO Category GO:0043021 ribonucleoprotein complex binding Database 0


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