bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: TFEB

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TFEB 0 1.760 0.270 0.450

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TFEB Phosphorylation S555 0.499 0.811 _RSSFS(ph)MEEGDVL_
TFEB Phosphorylation S541 -0.724 _KDLDLMLLDDSLLPLASDPLLSTMS(ph)PEASK_

Background Information for TFEB:


Pubmed-TFEB »
Uniprot-TFEB »
Biogrid-TFEB »
ProteomicsDB-TFEB »

Tumorportal-TFEB »
COSMIC-TFEB »
GenomeRNAi-TFEB »
Genecards-TFEB


Protein-protein Interactions for TFEB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TFEB Cat. description Hein, Mann, Cell 2015
Category members IP bait MITF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFEB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TFEB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32
Category members bHLH_ZIP_TF_MiT/TFE IPR021802 0


Protein complexes (CORUM database) featuring TFEB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TFEB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Disease phenotype Translocation_renal_cell_carcinoma Translocation renal cell carcinoma Database 0
Category members GO Category GO:0001892 embryonic placenta development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006914 autophagy Database 0
Category members GO Category GO:0006959 humoral immune response Database 0
Category members GO Category GO:0007040 lysosome organization Database 0
Category members GO Category GO:0010508 positive regulation of autophagy Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0


.

© Copyright Svejstrup Laboratory 2015