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Query: SLIT2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SLIT2 0 -1.818 -0.940 1.740 -3.112 -1.071

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SLIT2 Ubiquitylation K103 0.625 _GAFQDLK(gl)ELER_
SLIT2 Ubiquitylation K825 0.073 _TFDGLK(gl)SLR_
SLIT2 Ubiquitylation K72 -1.544 _ITK(gl)TDFAGLR_

Background Information for SLIT2:


Pubmed-SLIT2 »
Uniprot-SLIT2 »
Biogrid-SLIT2 »
ProteomicsDB-SLIT2 »

Tumorportal-SLIT2 »
COSMIC-SLIT2 »
GenomeRNAi-SLIT2 »
Genecards-SLIT2


Protein-protein Interactions for SLIT2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANKRD12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRICKLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SLIT2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF-like_Ca-bd_dom IPR001881 0.69
Category members Leu-rich_rpt_typical-subtyp IPR003591 0.57
Category members EGF_extracell IPR013111 0.46
Category members Leu-rich_rpt IPR001611 0.32
Category members Cys-rich_flank_reg_C IPR000483 0.21
Category members LRR-contain_N IPR000372 0.13
Category members Laminin_G IPR001791 0.06
Category members Cys_knot_C IPR006207 0.03
Category members Fol_N IPR003645 0.01
Category members ConA-like_lec_gl_sf IPR008985 0


Protein complexes (CORUM database) featuring SLIT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SLIT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0010596 negative regulation of endothelial cell migration Database 0.31
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0030837 negative regulation of actin filament polymerization Database 0.13
Category members GO Category GO:0022029 telencephalon cell migration Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0021772 olfactory bulb development Database 0.06
Category members GO Category GO:0048846 axon extension involved in axon guidance Database 0.05
Category members GO Category GO:0005095 GTPase inhibitor activity Database 0.05
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0002042 cell migration involved in sprouting angiogenesis Database 0.01
Category members GO Category GO:0001656 metanephros development Database 0
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members Pathway Pathway_1148 REACTOME_ACTIVATION_OF_RAC 0 0
Category members Pathway Pathway_692 REACTOME_NETRIN1_SIGNALING 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0008045 motor neuron axon guidance Database 0
Category members GO Category GO:0010593 negative regulation of lamellipodium assembly Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0014912 negative regulation of smooth muscle cell migration Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration Database 0
Category members GO Category GO:0031290 retinal ganglion cell axon guidance Database 0
Category members GO Category GO:0032870 cellular response to hormone stimulus Database 0
Category members GO Category GO:0033563 dorsal/ventral axon guidance Database 0
Category members GO Category GO:0035385 Roundabout signaling pathway Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043116 negative regulation of vascular permeability Database 0
Category members GO Category GO:0043237 laminin-1 binding Database 0
Category members GO Category GO:0043394 proteoglycan binding Database 0
Category members GO Category GO:0045499 chemorepellent activity Database 0
Category members GO Category GO:0048495 Roundabout binding Database 0
Category members GO Category GO:0048754 branching morphogenesis of an epithelial tube Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0050772 positive regulation of axonogenesis Database 0
Category members GO Category GO:0050919 negative chemotaxis Database 0
Category members GO Category GO:0051414 response to cortisol Database 0
Category members GO Category GO:0060603 mammary gland duct morphogenesis Database 0
Category members GO Category GO:0060763 mammary duct terminal end bud growth Database 0
Category members GO Category GO:0061364 apoptotic process involved in luteolysis Database 0
Category members GO Category GO:0070100 negative regulation of chemokine-mediated signaling pathway Database 0


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