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Query: SH3KBP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SH3KBP1 0 -0.056 -0.400 -0.020 -0.522

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SH3KBP1 Phosphorylation S230 0.300 0.186 _S(ph)IEVENDFLPVEK_

Background Information for SH3KBP1:


Pubmed-SH3KBP1 »
Uniprot-SH3KBP1 »
Biogrid-SH3KBP1 »
ProteomicsDB-SH3KBP1 »

Tumorportal-SH3KBP1 »
COSMIC-SH3KBP1 »
GenomeRNAi-SH3KBP1 »
Genecards-SH3KBP1


Protein-protein Interactions for SH3KBP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGAP44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAPZA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHMP5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GAS2L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPP5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3KBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCP10L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TP63 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF764 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SH3KBP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH3_domain IPR001452 0
Category members Spectrin_alpha_SH3 IPR013315 0


Protein complexes (CORUM database) featuring SH3KBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2453 Multiprotein complex (monoubiquitination) Database 0
Category members Corum 2454 CIN85-CBL-SH3GL2-EGFR complex, EGF stimulated Database 0
Category members Corum 2455 CIN85-SH3GL2 complex Database 0
Category members Corum 2456 MET-CIN85-SH3GL3-CBL complex, HGF stimulated Database 0
Category members Corum 2457 CIN85-SH3GL3 complex Database 0
Category members Corum 2480 CIN85 complex (CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, SOS1) Database 0
Category members Corum 3174 CIN85-BLNK complex Database 0
Category members Corum 3175 CIN85-c-CBL complex Database 0
Category members Corum 5171 SH3KBP1-CBLB-EGFR complex Database 0
Category members Corum 5720 CIN85-CBL complex Database 0
Category members Corum 5721 CIN85-CBL-SH3GL2 complex Database 0
Category members Corum 5724 CIN85-SH3GL3-CBL complex Database 0
Category members Corum 846 RICH1/AMOT polarity complex, Flag-Rich1 precipitated Database 0


Categories featuring SH3KBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members Pathway Pathway_1067 BIOCARTA_CBL_PATHWAY 0 0.14
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_659 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 0 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0


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