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Query: SH3GL1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SH3GL1 1 2.065 0.960 -1.010

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SH3GL1 Ubiquitylation K76 -0.032 1.606 _LTMLNTVSK(gl)IR_
SH3GL1 Ubiquitylation K177 -0.477 0.450 _QGK(gl)IPDEELR_
SH3GL1 Phosphorylation S287 -0.011 0.143 _IAASS(ph)SFR_
SH3GL1 Phosphorylation S288 0.348 -0.194 _IAASSS(ph)FR_
SH3GL1 Ubiquitylation K7 -0.268 _(ac)SVAGLK(gl)K_
SH3GL1 Ubiquitylation K8 -0.654 _(ac)SVAGLKK(gl)_

Background Information for SH3GL1:


Pubmed-SH3GL1 »
Uniprot-SH3GL1 »
Biogrid-SH3GL1 »
ProteomicsDB-SH3GL1 »

Tumorportal-SH3GL1 »
COSMIC-SH3GL1 »
GenomeRNAi-SH3GL1 »
Genecards-SH3GL1


Protein-protein Interactions for SH3GL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARHGAP8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AZU1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C8G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPPA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPX7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3GL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3GL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPTE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SH3GL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH3_domain IPR001452 0
Category members BAR_dom IPR004148 0
Category members BAR_dom-cont IPR018859 0


Protein complexes (CORUM database) featuring SH3GL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SH3GL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0002102 podosome Database 0.3
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0019902 phosphatase binding Database 0.16
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0042995 cell projection Database 0
Category members GO Category GO:0051020 GTPase binding Database 0


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